QUANTITATIVE INTER-SEGMENTAL AND INTER-LAMINAR COMPARISON OF CORTICOSPINAL PROJECTIONS FROM THE FORELIMB AREA OF THE PRIMARY MOTOR CORTEX OF MACAQUE MONKEYS
QUANTITATIVE INTER-SEGMENTAL AND INTER-LAMINAR COMPARISON OF CORTICOSPINAL PROJECTIONS FROM THE FORELIMB AREA OF THE PRIMARY MOTOR CORTEX OF MACAQUE MONKEYS
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DOI：
10.1016/j.neuroscience.2010.10.007
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发表时间：
2010-12-29
期刊：
影响因子：
3.3
通讯作者：
Isa, T.
中科院分区：
文献类型：
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作者：
Yoshino-Saito, K.;Nishimura, Y.;Isa, T.
使用高分辨率顺行示踪剂、生物素化右旋糖胺 (BDA) 对恒河猴 (n=5) 中从初级运动皮层前肢区域到 C2-Th2 脊髓节段的皮质脊髓投射进行定量分析。大多数下降轴突位于对侧背外侧索 (DLF) (85-98%)，但在同侧 DLF 中观察到一小部分(1-12%) 和腹内侧索 (VMF) (1-7%) 在灰质中，轴突侧支和末端纽扣主要存在于对侧 VI-VII 和 IX 层以及同侧 VIII 层。向对侧灰质的投射大部分来自对侧 DLF，但少数来自同侧 DLF 来自同侧 DLF 的轴突未发现在对侧灰质上投射侧支另一方面，向同侧 VIII 板的投影来自同侧 VMF，连合轴突来自对侧 IX 板运动神经元池中的对侧 DLF 末端按钮，主要发现于 C7-Th1 脊髓段，而向对侧 VI-VII 的投影则来自同侧 VIII 板，在更多的吻端节段中也发现了连合轴突，大量存在于 C4-C8 节段、运动神经元投影的吻端 1-3 个节段。这些结果表明，对侧前肢运动神经元的皮质控制伴随着对侧 VI-VII 层和同侧 VIII 层中神经元系统的调节，位于运动神经元吻端的几个节段 (C) 2010 IBRO 爱思唯尔有限公司出版版权所有
Corticospinal projections from the forelimb area of the primary motor cortex to the C2-Th2 spinal cord segments were quantitatively analyzed using the high resolution anterograde tracer, biotinylated dextran amine (BDA) in rhesus monkeys (n=5) The majority of descending axons were located in the contralateral dorsolateral funiculus (DLF) (85-98%), but a minor portion was observed in the ipsilateral DLF (1-12%) and ventromedial funiculus (VMF) (1-7%) In the gray matter, axon collaterals and terminal buttons were found mainly in the contralateral laminae VI-VII and IX and ipsilateral lamina VIII The majority of projections to the contralateral gray matter originated from the contralateral DLF, but a minority originated from the ipsilateral DLF Axons from the ipsilateral DLF were not found to project collaterals on the ipsilateral side, but directly entered the contralateral side after crossing the midline On the other hand, projections to the ipsilateral lamina VIII were from the ipsilateral VMF, and commissural axons were from the contralateral DLF Terminal buttons in the motoneuron pool in the contralateral lamina IX were found mainly at the C7-Th1 spinal cord segments, whereas the projections to the contralateral laminae VI-VII ipsilateral lamina VIII, and commissural axons were also found in more rostral segments, abundantly at the C4-C8 segments, 1-3 segments rostral to the motoneuronal projections These results suggest that cortical control of contralateral forelimb motoneurons accompanies regulation of inter neuronal systems in the contralateral laminae VI-VII and the ipsilateral lamina VIII located a few segments rostral to the motoneurons (C) 2010 IBRO Published by Elsevier Ltd All rights reserved