Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA
Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA
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DOI：
10.1016/0140-6736(90)92693-c
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发表时间：
1990-05
期刊：
影响因子：
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通讯作者：
G. Riou;M. Fãvre;D. Jeannel;J. Bourhis;V. Doussal;G. Orth
中科院分区：
文献类型：
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作者：
G. Riou;M. Fãvre;D. Jeannel;J. Bourhis;V. Doussal;G. Orth
用Southern杂交和聚合酶链反应检测了106例早期宫颈浸润癌中84%的人乳头瘤病毒（HPV）DNA序列（HPV 16、18、33、35型或未鉴定型）。在HPV阳性患者中，总体复发风险与个体HPV类型没有差异。与HPV阳性患者相比，HPV DNA阴性患者的总体复发风险高2.6倍（p<0.05），远处转移风险高4.5倍（p <0.01）。HPV阳性患者的24个月无复发生存率显著高于HPV阴性患者（77% vs 40%），淋巴结阴性患者的差异相似（91% vs 56%）。这些数据表明，HPV阴性宫颈癌可能代表了一个生物学上不同的肿瘤子集，其预后比HPV阳性癌症差。
Human papilloma virus (HPV) DNA sequences (HPV types 16,18, 33, 35 or uncharacterised) were detected by Southern blot hybridisation and polymerase chain reaction in 84% of 106 early-stage invasive carcinomas of the uterine cervix. Among HPV-positive patients, the risk of overall relapse did not differ with individual HPV types. Compared with HPV-positive patients, those with no detectable HPV DNA had a 2·6 times higher risk of overall relapse (p<0·05) and 4·5 times higher risk of distant metastases (p <0·01). The 24-month relapse-free survival rate in HPV-positive patients was significantly higher than that in HPV-negative patients (77% vs 40%), and the difference was similar (91% vs 56%) among those who were node-negative. These data indicate that HPV-negative cervical carcinomas may represent a biologically distinct subset of tumours that carry a poorer prognosis than do HPV-positive cancers.