Direct repeats in mitochondrial DNA and mammalian lifespan
Direct repeats in mitochondrial DNA and mammalian lifespan
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DOI：
10.1016/j.mad.2006.07.008
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发表时间：
2006-10-01
影响因子：
5.3
通讯作者：
Shmookler Reis, Robert J.
中科院分区：
文献类型：
--
作者：
Khaidakov, Magomed;Siegel, Eric R.;Shmookler Reis, Robert J.
长期以来，线粒体一直被怀疑是衰老的主要决定因素之一，因为它们的功能重要性，以及线粒体DNA突变的积累导致的加速退化。已知直接重复序列有助于线粒体DNA的缺失形成，是不依赖于活性氧(ROS)的突变的强大来源。为了评估基于同源性的缺失形成的潜在重要性，我们分析了mtDNA序列中的直接重复与65个哺乳动物物种的寿命之间的关联。在这里，我们报告了直接重复序列的突变潜力与哺乳动物寿命之间的显著负相关，这在密切相关的物种中尤其明显。(C)2006爱思唯尔爱尔兰有限公司。保留所有权利。
Mitochondria have long been suspected to be among the leading determinants of aging due to their functional importance and accelerated deterioration caused by accumulation of mutations in the mitochondfial DNA. Direct repeats are known to contribute to deletion formation in mtDNA and are a powerful source of reactive oxygen species (ROS)-independent mutagenesis. To evaluate the potential importance of homology-based deletion formation, we have analyzed the association between direct repeats in the mtDNA sequence and the lifespans of 65 mammalian species. Here, we report a significant negative correlation between the mutagenic potential of direct repeats and the mammalian lifespan, which is especially evident in closely related species. (c) 2006 Elsevier Ireland Ltd. All rights reserved.