Recent successes of the energy landscape theory of protein folding and function
Recent successes of the energy landscape theory of protein folding and function
复制标题
蛋白质折叠和功能的能量景观理论的最新成功
DOI：
--
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
P. Wolynes
中科院分区：
文献类型：
--
作者：
P. Wolynes
蛋白质的折叠和结合可以用能量景观理论来解释。当发现表面上与漏斗假说的预测有偏差时，景观理论帮助我们定位原因。有时，偏差反映了对称效应，允许发生额外的简并。这种效应似乎解释了螺旋束中的一些动力学反常现象。当结合过程被发现使用明显非漏斗的景观时，这被追溯到对生物分子作用力的理解不足。这种差异允许发现新的水介导力--其中一些作用于亲水残基之间。将这种力引入算法中，极大地提高了结构预测的质量。
Protein folding and binding can be understood using energy landscape theory. When seeming deviations from the predictions of the funnel hypothesis are found, landscape theory helps us locate the cause. Sometimes the deviation reflects symmetry effects, allowing extra degeneracies to occur. Such effects seem to explain some kinetic anomalies in helical bundles. When binding processes were found to use apparently non-funneled landscapes this was traced to an inadequate understanding of biomolecular forces. The discrepancy allowed the discovery of new water-mediated forces – some of which act between hydrophilic residues. Introducing such forces into the algorithms greatly improves the quality of structure predictions.
DOI：
10.1073/pnas.160259697
发表时间：
2000-08-01
影响因子：
11.1
作者：
Shoemaker, BA;Portman, JJ;Wolynes, PG
通讯作者：
Wolynes, PG
DOI：
10.1073/pnas.0307851100
发表时间：
2004-03-09
影响因子：
11.1
作者：
Papoian, GA;Ulander, J;Wolynes, PG
通讯作者：
Wolynes, PG
影响因子：
15
作者：
Papoian, GA;Ulander, J;Wolynes, PG
通讯作者：
Wolynes, PG