Colonic movements in healthy subjects as monitored by a Magnet Tracking System
Colonic movements in healthy subjects as monitored by a Magnet Tracking System
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DOI：
10.1111/j.1365-2982.2009.01298.x
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发表时间：
2009-08-01
影响因子：
3.5
通讯作者：
Kucera, P.
中科院分区：
文献类型：
--
作者：
Hiroz, P.;Schlageter, V.;Kucera, P.
磁体追踪系统（MTS）是一种持续评估胃肠运动的微创技术。在这项研究中，MTS用于分析结肠推进动力学，并比较磁性药丸与标准放射性不透明标记物的传输。MTS实时监测磁性药丸通过肠道的过程。10名每天排便规律的男性和10名女性在晚上8点吞下这种药片和10个不透明的标记物。在接下来的两个早晨进行了5个小时的录音。相对于弹丸轨迹的时空图，分析了弹丸运动的起源、方向、幅度和速度。采用腹部x线片比较药丸和标记物的进展。磁性药丸在结肠中停留的时间有90%是闲置的；其总逆行位移仅占其总位移的20%。对这些运动的分析显示了速度的双峰分布：大约1.5和50厘米分钟（-1），后者负责2/3的穿越距离。总体上，男性群体的运动更多。左结肠的净每小时前进速度大于右结肠，男性更大。磁丸的位置与标记物的进展密切相关。MTS显示了结肠节段的模式和推进动力学，其精度尚未达到。详细分析结肠进展的慢速和快速模式，可以明确结肠节段的运动性，以及性别上的任何变异。这样的分析为运动障碍的研究开辟了有希望的途径。
P>The Magnet Tracking System (MTS) is a minimally-invasive technique of continuous evaluation of gastrointestinal motility. In this study, MTS was used to analyse colonic propulsive dynamics and compare the transit of a magnetic pill with that of standard radio-opaque markers. MTS monitors the progress in real time of a magnetic pill through the gut. Ten men and 10 women with regular daily bowel movements swallowed this pill and 10 radio-opaque markers at 8 pm. Five hours of recordings were conducted during 2 following mornings. Origin, direction, amplitude and velocity of movements were analysed relative to space-time plots of the pill trajectory. Abdominal radiographs were taken to compare the progress of both pill and markers. The magnetic pill lay idle for 90% of its sojourn in the colon; its total retrograde displacement accounted for only 20% of its overall movement. Analysis of these movements showed a bimodal distribution of velocities: around 1.5 and 50 cm min(-1), the latter being responsible for 2/3 of distance traversed. There were more movements overall and more mass movements in males. Net hourly forward progress was greater in the left than right colon, and greater in males. The position of the magnetic pill correlated well with the advancement of markers. MTS showed patterns and propulsion dynamics of colonic segments with as yet unmet precision. Detailed analysis of slow and fast patterns of colonic progress makes it possible to specify the motility of colonic segments, and any variability in gender. Such analysis opens up promising avenues in studies of motility disorders.