Cardiometabolic risk factors and insulin resistance in obese children and adolescents: relation to puberty
Cardiometabolic risk factors and insulin resistance in obese children and adolescents: relation to puberty
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DOI：
10.1111/j.2047-6310.2013.00202.x
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发表时间：
2015-02-01
影响因子：
3.8
通讯作者：
Barkai, L.
中科院分区：
文献类型：
--
作者：
Tobisch, B.;Blatniczky, L.;Barkai, L.
研究背景胰岛素抵抗（IR）在肥胖儿童的代谢改变中起着重要作用。在青春期开始时，胰岛素水平升高。目前还不清楚，但是，如何胰岛素水平的发展，如果代谢syndrome appears.ObjectivesMetabolic的变化进行了评估，在肥胖儿童青春期前，期间和之后，分析IR和青春期之间的关系，在受试者和无metabolic syndrome. MethodsThirty 34肥胖儿童（5-19岁）参加了这项研究。采用国际糖尿病联合会的标准评估心脏代谢风险（CMR）的存在。将CMR增加的受试者与无风险受试者（nCMR）进行比较。在口服葡萄糖耐量试验期间测定每个参与者的青春期分期、血脂水平、血糖和胰岛素水平。结果青春期前CMR组AUC-IR显著高于nCMR组（11.84 ± 1.03 vs.8.00 ± 0.69; P
BackgroundInsulin resistance (IR) has a key role in the metabolic changes in obese children. In commencing puberty, the insulin levels elevate. It is not clear, however, how insulin levels develop if the metabolic syndrome appears.ObjectivesMetabolic changes were assessed in obese children before, during and after puberty to analyse the relationship between IR and puberty in subjects with and without metabolic syndrome.MethodsThree hundred thirty-four obese children (5-19 years) attended the study. The criteria of the International Diabetes Federation were used to assess the presence of cardiometabolic risks (CMRs). Subjects with increased CMR were compared with those without risk (nCMR). Pubertal staging, lipid levels, plasma glucose and insulin levels during oral glucose tolerance test were determined in each participant. IR was expressed by homeostasis model assessment (HOMA-IR) and the ratio of glucose and insulin areas under the curve (AUC-IR).ResultsSignificantly higher AUC-IR were found in pre-pubertal CMR children compared with nCMR subjects (11.841.03 vs. 8.00 +/- 0.69; P