Parental occupations and childhood brain tumors: results of an international case-control study
Parental occupations and childhood brain tumors: results of an international case-control study
复制标题
DOI：
10.1023/a:1012277703631
复制
发表时间：
2001-11-01
影响因子：
2.3
通讯作者：
Arslan, A
中科院分区：
文献类型：
--
作者：
Cordier, S;Mandereau, L;Arslan, A
目的：评估父母职业在儿童脑肿瘤（CBT）病因中的作用。方法：在国际癌症研究机构的协调下，在7个国家同时进行了以人群为基础的病例对照研究，收集了1218例病例和2223例对照。我们在这里报告的调查结果有关的父母的职业在5年期间之前的孩子的出生。一些父亲和母亲的职业相关的风险估计获得了无条件logistic回归调整年龄，性别，出生年份，和中心，为所有类型的CBT相结合，并为亚组的星形胶质细胞，原始神经外胚层肿瘤（PNET），和其他glial tumors.Results：增加的风险与农业工作的所有CBT相结合，并为其他胶质肿瘤。所有肿瘤和PNET的风险增加被认为是父亲的职业作为一个电工，同样的模式举行了母亲的职业时，5岁以下的儿童被选中。父亲职业为司机或机械师，母亲在与机动车相关的环境中工作与所有CBT和星形胶质细胞肿瘤的风险增加相关。更多的情况下，母亲相比，控制母亲受雇于纺织industrial.Conclusion：我们的研究加强了以前的研究结果相对于父母的工作在农业，电力，或机动车相关的职业和母亲的工作在纺织行业的作用。它没有证实以前与航空航天、化学工业或食品工业等工作环境的联系，也没有证实母亲的职业是理发师、护士或缝纫机师，父亲的职业是焊工。
Objective: To evaluate the role of parental occupations in the etiology of childhood brain tumors (CBT).Methods: Population-based case-control studies were conducted concurrently in seven countries under the coordination of the International Agency for Research on Cancer, gathering 1218 cases and 2223 controls. We report here the findings related to parental occupations during the 5-year period before the child's birth. Risk estimates related to a number of paternal and maternal occupations were obtained by unconditional logistic regression adjusted for age, sex, year of birth, and center, for all types of CBT combined and for the subgroups of astroglial, primitive neuroectodermal tumors (PNET), and other glial tumors.Results: An increased risk in relation with agricultural work was seen for all CBT combined and for other glial tumors. Increased risks for all tumors and PNET were seen for paternal occupation as an electrician; the same pattern held for maternal occupation when children under 5 were selected. Paternal occupation as a driver or mechanic, and maternal work in an environment related to motor-vehicles were associated with an increased risk for all CBT and astroglial tumors. More case mothers compared to control mothers were employed in the textile industry.Conclusion: Our study reinforces previous findings relative to the role of parental work in agriculture, electricity, or motor-vehicle related occupations and maternal work in the textile industry. It does not confirm previous associations with work environments including aerospace, the chemical industry, or the food industry, or with maternal occupation as a hairdresser, a nurse, or a sewing machinist, and paternal occupation as a welder.