Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics.
Arabinosylcytosine induces fetal hemoglobin in baboons by perturbing erythroid cell differentiation kinetics.
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阿拉伯糖胞嘧啶通过扰乱红细胞分化动力学来诱导狒狒胎儿血红蛋白。
DOI：
10.1126/science.6200940
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Stamatoyannopoulos,G
中科院分区：
文献类型：
--
作者：
Papayannopoulou,T;TorrealbadeRon,A;Veith,R;Knitter,G;Stamatoyannopoulos,G
阿糖胞苷是一种抑制快速分裂细胞中DNA合成的化合物，可刺激成年狒狒的胎儿血红蛋白，并对红系祖细胞库产生重大干扰。似乎是红系细胞分化动力学的变化，而不是对γ基因的直接作用，是体内成年动物中胎儿血红蛋白刺激的基础。这些结果还表明，选择低致癌性或致突变性的化疗药物可用于镰状细胞性贫血患者的胎儿血红蛋白治疗诱导。
Arabinosylcytosine, a compound that inhibits DNA synthesis in rapidly dividing cells, stimulates fetal hemoglobin in adult baboons and produces significant perturbations in the pools of erythroid progenitors. It appears that changes in the kinetics of erythroid cell differentiation rather than direct action on the γ genes underlie stimulation of fetal hemoglobin in the adult animals in vivo. These results also suggest that chemotherapeutic agents selected for their low carcinogenic or mutagenic potential could be used for therapeutic induction of fetal hemoglobin in patients with sickle cell anemia.