[Reduced resistin levels in patients with type 2 diabetes mellitus].
[Reduced resistin levels in patients with type 2 diabetes mellitus].
复制标题
[2型糖尿病患者抵抗素水平降低]。
作者：
Jing Yang;Ming Li;Cong;Hong Wang;Qishan Xu;Jie
目的
测定2型糖尿病患者的血清肌酐水平，探讨肌酐与肥胖及糖尿病之间的关系。
方法
采用酶联免疫吸附试验（ELISA）检测51例2型糖尿病患者（男30例，女21例）和52例正常对照者空腹及服75 g葡萄糖后2 h血清瘦素、真胰岛素和β-谷氨酰胺。测量血糖、血压、身高、体重、腰围、臀围。计算体重指数（BMI）、腰臀比（WHR）和定量胰岛素敏感性检查指数（QUICKI）。
结果
与对照组相比，糖尿病组腰臀比（WHR）和血清胰岛素水平明显升高（P < 0.05），但空腹状态和空腹状态下的血清肌酐水平均显著降低（P < 0.05（23 ng/ml +/-15 ng/ml vs 30 ng/ml +/-18 ng/ml，P < 0.05）和葡萄糖负荷后2小时（22 ng/ml +/-11 ng/ml vs 31 ng/ml +/-15 ng/ml，P < 0.001）。两组患者血清瘦素水平差异无统计学意义（P > 0.05）。葡萄糖负荷后2小时，两组间的β-淀粉样蛋白水平无显著差异。相关分析显示，空腹血清瘦素水平与性别、BMI、瘦素、血压无相关性，与QUICKI呈正相关（r = 0.30，P < 0.01），与血糖呈负相关（r =-0.21，P < 0.05）。
结论
2型糖尿病患者空腹状态及葡萄糖摄入后2小时血清谷丙转氨酶水平不升高而降低。抵抗素可能不是人类肥胖和糖尿病之间的主要联系。由于人的胰岛素抵抗蛋白水平与胰岛素敏感性正相关，因此最初用于其对胰岛素的抗性的术语“胰岛素抵抗蛋白”的使用可能有些过早。
OBJECTIVE
To measure the serum resistin level of patients with type 2 diabetes mellitus so as to examine whether there exists a relationship between resistin, obesity and diabetes.
METHODS
ELISA was used to examine the fasting serum resistin, leptin, and true insulin and those 2-hours after taking 75-g glucose in 51 untreated type 2 diabetic patients, 30 males and 21 females, and 52 sex and age-matched normal control subjects. Blood glucose, blood pressure, height, weight, waist circumstance, hip girth were measured. Body mass index (BMI), waist to hip ratio (WHR), and quantitative insulin sensitivity check index (QUICKI) were calculated.
RESULTS
In comparison with the control, the diabetic group had higher waist-to-hip ratio (WHR) and serum insulin levels (P < 0.05), but significantly lower resistin levels both in the fasting status (23 ng/ml +/- 15 ng/ml vs 30 ng/ml +/- 18 ng/ml, P < 0.05) and 2 hours after glucose loading (22 ng/ml +/- 11 ng/ml vs 31 ng/ml +/- 15 ng/ml, P < 0.001). The leptin level was not statistically different between the two groups (P > 0.05). The resistin level 2 hours after glucose loading was not significantly different between these 2 groups. Correlation analysis demonstrated that fasting resistin level was not correlated with sex, BMI, leptin, and blood pressure, but positively correlated with QUICKI (r = 0.30, P < 0.01) and negatively correlated with blood glucose (r = -0.21, P < 0.05).
CONCLUSION
The serum resistin level of patients with type 2 diabetes is reduced rather than increased in fasting status and 2 hours after glucose taking. Resistin may not be the major link between obesity and diabetes in human beings. Since human resistin level is positively correlated with insulin sensitivity, the use of term "resistin", originally for its resistance to insulin, may be somewhat premature.