Basis for detection of stenosis using venous administration of microbubbles during myocardial contrast echocardiography: Bolus or continuous infusion?
Basis for detection of stenosis using venous administration of microbubbles during myocardial contrast echocardiography: Bolus or continuous infusion?
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DOI：
10.1016/s0735-1097(98)00212-5
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发表时间：
1998-07-01
影响因子：
24
通讯作者：
Kaul, S
中科院分区：
文献类型：
--
作者：
Wei, K;Jayaweera, AR;Kaul, S
目标。本研究旨在确定使用静脉给药微泡的心肌超声造影检测狭窄的基础，并确定大剂量注射与持续输注的相对优点。背景：血管狭窄与正常冠状动脉供血心肌床的视像强度（VI）差异程度可用于量化静脉给药后血管狭窄的严重程度。然而，微泡作为单次注射或连续输注的比较优点尚未得到研究。在18只狗的左前降支或左旋支冠状动脉中产生了不同程度的冠状动脉狭窄。Imagent US （AF0150）在10只犬（第一组）中作为单次注射，在8只犬（第二组）中作为单次注射和连续输注。对于大剂量注射，峰值VI由时间强度图得出。在连续输注期间，微泡速度和微血管横截面积由脉冲间隔与VI图得出。用放射性标记微球测定心肌血容量。充血期间，狭窄床与正常床的VI比值与静脉注射（r = 0.81）和持续输注（r = 0.79）的放射性标记微球衍生MBF比值相关。两种技术检测狭窄的共同基础是充血期间狭窄远端心肌血容量的减少。连续输注相对于单次注射的优势在于消除后壁衰减和量化mbf的能力。小丸注射和连续输注均可定量评估相对狭窄的严重程度，与小丸注射相比，连续输注还可以量化MBF和数据采集，而不会对任何心肌床造成衰减。(C) 1998年由美国心脏病学会发布。
Objectives. This study sought to determine the basis of detection of stenosis by myocardial contrast echocardiography using venous administration of microbubbles and to define the relative merits of bolus injection versus continuous infusion.Background, The degree of video intensity (VI) disparity in myocardial beds supplied by stenosed and normal coronary arteries can be used to quantify stenosis severity after venous administration of microbubbles. However, the comparative merits of administering microbubbles as a bolus injection or continuous infusion has not been studied.Methods. Coronary stenoses of varying severity were created in either the left anterior descending or the left circumflex coronary artery in 18 dogs. Imagent US (AF0150) was given as a bolus injection in 10 dogs (Group I) and as both a bolus injection and a continuous infusion in 8 dogs (Group II). For bolus injections, peak VI was derived from time-intensity plots. During continuous infusion, microbubble velocity and microvascular cross-sectional area were derived from pulsing interval versus VI plots. Myocardial blood how (MBF) was determined using radiolabeled microspheres,Results. During hyperemia, VI ratios from the stenosed versus normal beds correlated with radiolabeled microsphere-derived MBF ratios from those beds for both bolus injections (r = 0.81) and continuous infusion (r = 0,79), The basis for detection of stenosis common to both techniques was the decrease in myocardial blood volume distal to the stenosis during hyperemia, The advantage of continuous infusion over bolus injection,vas the abolition of posterior wall attenuation and the ability to quantify MBF.Conclusions. Both bolus injection and continuous infusion provide quantitative assessment of relative stenosis severity, Compared with bolus injection, continuous infusion also allows quantification of MBF and data acquisition without attenuation of any myocardial bed. (C) 1998 by the American College of Cardiology.