Metabolic mapping of the primary visual system of the monkey by means of the autoradiographic [14C]deoxyglucose technique.
Metabolic mapping of the primary visual system of the monkey by means of the autoradiographic [14C]deoxyglucose technique.
复制标题
通过放射自显影[14C]脱氧葡萄糖技术绘制猴子初级视觉系统的代谢图。
DOI：
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发表时间：
1976
影响因子：
11.1
通讯作者：
Louis Sokoloff
中科院分区：
文献类型：
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作者：
Charles Kennedy;M. D. Rosiers;O. Sakurada;M. Shinohara;Martin Reivich;J. Jehle;Louis Sokoloff
采用2-[14-C]脱氧葡萄糖测量脑内葡萄糖利用率的放射自显影技术已应用于猕猴的双眼视觉系统。这种方法可以形象地显示大脑组成结构中葡萄糖消耗的相对速率，由于功能活动与能量代谢之间的密切关系，因此可以描绘出功能活动改变的区域。双侧视网膜刺激导致在至少四个细胞结构层的纹状皮质中描绘不同的葡萄糖消耗速率。最强烈的代谢活动似乎是在第四层，终止的膝状皮质途径的轨迹。双侧视觉阻断降低了纹状体皮质的葡萄糖消耗率，并显著减少了各层的代谢分化。单侧视觉剥夺描绘了外侧膝状体的板层和纹状皮质的眼优势柱。它还导致放射自显影的区域与正常单眼输入的纹状体皮质，如在距状皮质的蘑菇状配置的喙部，这代表了极端的时间新月的视野，和蘑菇配置的最尾部的小区域，这被认为是代表皮质位点的盲点的视野。
An autoradiographic technique that employs 2-[14-C]deoxyglucose to measure the local rates of glucose utilization within the brain has been applied to the binocular visual system of the Macaque monkey. This method, which pictorially displays the relative rates of glucose consumption in the component structures of the brain, delineates the regions of altered functional activity because of the close relationship between functional activity and energy metabolism. Bilateral retinal stimulation results in the delineation of different rates of glucose consumption in at least four cytoarchitectural layers of the striate cortex. The most intense metabolic activity appears to be in Layer IV, the locus of the termination of the geniculocortical pathway. Bilateral visual occlusion lowers the rates of glucoes consumption in striate cortex and markedly reduces the metabolic differentiation of the various layers. Unilateral visual deprivation delineates the laminae of the lateral geniculate body and the ocular dominance columns of the striate cortex. It also results in the autoradiographic visualization of regions with normally monocular input in the striate cortex, such as the rostral portions of the mushroom-like configurations in the calcarine cortex, which represent the extreme temporal crescents of the visual fields, and small regions in the most caudal part of the mushroom configurations, which are believed to represent the cortical loci of the blind spotsof the visual fields.