Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway
Functional feedback from mushroom bodies to antennal lobes in the Drosophila olfactory pathway
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DOI：
10.1073/pnas.0914912107
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发表时间：
2010-06-01
影响因子：
11.1
通讯作者：
Wang, Zuoren
中科院分区：
文献类型：
--
作者：
Hu, Aiqun;Zhang, Wei;Wang, Zuoren
反馈在感觉处理中发挥着重要作用。蘑菇体被认为参与昆虫的嗅觉学习/记忆和多感觉整合。以前的钴标记研究表明，蜜蜂的蘑菇体对触角叶存在反馈。本研究通过果蝇蘑菇体Kenyon细胞中ATP受体P2 X（2）的异位表达来研究蘑菇体对触角叶的功能反馈。凯尼恩细胞的激活引起的去极化投射神经元和局部interneurons在触角叶的烟碱受体依赖性的方式。在蘑菇体中的β-γ叶中的凯尼恩细胞轴突的激活比凯尼恩细胞胞体的激活在触角叶神经元中诱导更有效的反应。我们的结果表明，果蝇中存在从凯尼恩细胞到投射神经元和局部中间神经元的功能反馈，并且很可能是由β γ叶介导的。从蘑菇体到触角叶的这种功能反馈的存在表明果蝇的嗅觉信息处理是自上而下的调制。
Feedback plays important roles in sensory processing. Mushroom bodies are believed to be involved in olfactory learning/memory and multisensory integration in insects. Previous cobalt-labeling studies have suggested the existence of feedback from the mushroom bodies to the antennal lobes in the honey bee. In this study, the existence of functional feedback from Drosophila mushroom bodies to the antennal lobes was investigated through ectopic expression of the ATP receptor P2X(2) in the Kenyon cells of mushroom bodies. Activation of Kenyon cells induced depolarization in projection neurons and local interneurons in the antennal lobes in a nicotinic receptor-dependent manner. Activation of Kenyon cell axons in the beta gamma-lobes in the mushroom body induced more potent responses in the antennal lobe neurons than activation of Kenyon cell somata. Our results indicate that functional feedback from Kenyon cells to projection neurons and local interneurons is present in Drosophila and is likely mediated by the beta gamma-lobes. The presence of this functional feedback from the mushroom bodies to the antennal lobes suggests top-down modulation of olfactory information processing in Drosophila.