Elevated SCF levels in the serum of patients with chronic renal failure
Elevated SCF levels in the serum of patients with chronic renal failure
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DOI：
10.1046/j.1365-2141.1998.00902.x
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发表时间：
1998-09-01
影响因子：
6.5
通讯作者：
Nakagawa, S
中科院分区：
文献类型：
--
作者：
Kitoh, T;Ishikawa, H;Nakagawa, S
测定慢性肾功能衰竭（CRF）和贫血患者血清干细胞因子（SCF）和可溶性KIT（sKIT）水平，并与血细胞和肾功能等临床指标进行比较。CRF患者血清SCF水平是健康对照组的5倍。然而，血液透析（HD）-CRF患者的血清sKIT水平仅略高于健康对照组。在未治疗的CRF患者和健康对照组中，血清SCF水平与血尿素氮（BUN）、肌酐、血红蛋白、红细胞（RBC）计数和sKIT显著相关。在未治疗的CRF患者中，血清SCF水平与BUN、肌酐和sKIT显著相关。结果提示，SCF水平随肾功能恶化而升高，可能与红细胞生成有关。
Serum stem cell factor (SCF) and soluble KIT (sKIT) levels were estimated in patients with chronic renal failure (CRF) and anaemia, and compared with clinical parameters of blood cells and renal function. Serum SCF levels in CRF patients were 5-fold higher than those in healthy controls. However, serum sKIT levels in haemodialysis (HD)-CRF patients were only slightly higher than those of healthy controls. In untreated CRF patients and healthy controls, serum SCF levels were significantly correlated with blood urea nitrogen (BUN), creatinine, haemoglobin, red blood cell (RBC) count and sKIT. In untreated CRF patients, serum SCF levels were significantly correlated with BUN, creatinine, and sKIT. These results suggest that serum SCF levels increased with the deterioration of renal function and might be related to erythropoiesis.