The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.
The tandem endocytic receptors megalin and cubilin are important proteins in renal pathology.
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DOI：
10.1046/j.1523-1755.2002.00501.x
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发表时间：
2002-09
影响因子：
19.6
通讯作者：
P. Verroust;H. Birn;R. Nielsen;R. Kozyraki;E. Christensen
中科院分区：
文献类型：
--
作者：
P. Verroust;H. Birn;R. Nielsen;R. Kozyraki;E. Christensen
近端小管重吸收蛋白质的分子调控机制近年来得到了很大的研究。Megalin和cubilin构成参与该过程的两种重要的内吞受体蛋白。尽管结构上非常不同，但这两种受体蛋白相互作用以介导大量过滤蛋白的重吸收，包括对几种维生素、脂质和其他营养素的运输和细胞摄取重要的载体蛋白。任何一种蛋白质的功能障碍都会导致肾小管蛋白尿，并且与由于载体蛋白的近端肾小管重吸收缺陷引起的维生素代谢的特定变化相关。额外的重点是两个受体被吸引的可能致病作用的条件下，增加过滤的蛋白质，并通过最近的研究结果牵连成员的低密度脂蛋白受体家族，其中包括巨蛋白，在信号转导与细胞质蛋白的关联。
The molecular mechanisms controlling proximal tubule reabsorption of proteins have been much elucidated in recent years. Megalin and cubilin constitute two important endocytic receptor proteins involved in this process. Although structurally very different the two receptor proteins interact to mediate the reabsorption of a large number of filtered proteins, including carrier proteins important for transport and cellular uptake of several vitamins, lipids and other nutrients. Dysfunction of either protein results in tubular proteinuria and is associated with specific changes in vitamin metabolism due to the defective proximal tubular reabsorption of carrier proteins. Additional focus on the two receptors is attracted by the possible pathogenic role of excessive tubular protein uptake during conditions of increased filtration of proteins, and by recent findings implicating members of the low density lipoprotein-receptor family, which includes megalin, in the transduction of signals by association with cytoplasmic proteins.