VARIANTS OF ALPHA-MELANOCYTE STIMULATING HORMONE IN RAT-BRAIN AND PITUITARY - EVIDENCE THAT ACETYLATED ALPHA-MSH EXISTS ONLY IN THE INTERMEDIATE LOBE OF PITUITARY
VARIANTS OF ALPHA-MELANOCYTE STIMULATING HORMONE IN RAT-BRAIN AND PITUITARY - EVIDENCE THAT ACETYLATED ALPHA-MSH EXISTS ONLY IN THE INTERMEDIATE LOBE OF PITUITARY
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DOI：
10.1016/0006-291x(82)91797-1
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发表时间：
1982-01-01
影响因子：
3.1
通讯作者：
BARCHAS, JD
中科院分区：
文献类型：
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作者：
EVANS, CJ;LORENZ, R;BARCHAS, JD
用放射免疫分析结合不同的层析系统，详细分析了大鼠和人垂体和大鼠脑的α-MSH变异体。在大鼠脑区或人类脑下垂体的提取液中未检测到真正的α-MSH。在这些组织中检测到的唯一α-MSH变异体的特征是去乙酰化α-MSH。相反，乙酰化的α-MSH是大鼠脑垂体中的主要形式。除α-MSH外，大鼠和奶牛脑垂体提取物中都含有α-MSH变异体，具有O-N-双乙酰衍生物的特征。
The .alpha.-MSH variants from rat and human pituitary and rat brain were analyzed in detail by radioimmunoassay interfacing with various chromatography systems. No authentic .alpha.-MSH was detected in extracts of rat brain regions or human pituitary. In these tissues the only .alpha.-MSH variant detected was characterized as des-acetyl .alpha.-MSH. Conversely, acetylated .alpha.-MSH was the predominant form in rat pituitary. In addition to .alpha.-MSH, extracts from both rat and cow pituitary contained an .alpha.-MSH variant with the characteristics of an O-N-diacetyl derivative.