A natural polysaccharide-based antibacterial functionalization strategy for liquid and air filtration membranes
A natural polysaccharide-based antibacterial functionalization strategy for liquid and air filtration membranes
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基于天然多糖的液体和空气过滤膜抗菌功能化策略
DOI：
10.1039/d1tb02273c
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发表时间：
2021
影响因子：
7
通讯作者：
Fujian Xu
中科院分区：
文献类型：
--
作者：
Ruonan Wu;Mengkai Song;D;an Sui;Shun Duan;Fujian Xu
过滤膜广泛应用于医学领域。然而，这些膜受到医院细菌污染的挑战，这增加了医院感染的风险。因此，开发抗菌过滤膜具有重要意义。在这项工作中，氧化葡聚糖（ODex）为基础的抗菌涂层的设计和微过滤（MF）膜和熔喷织物上构建。合成了聚胍（PHMG）作为抗菌剂，并将其固定在滤膜上。功能化微滤膜提高了对大肠杆菌的过滤效率。大肠杆菌从20.9%提高到99.9%，对内毒素的吸收率提高了59.1%，而水流量仍然保持高达5255 L（h m2）−1。此外，捕获的细菌被抗菌涂层灭活。对于熔喷织物，气溶胶过滤效率从74.6%提高到81.0%，抗菌效率提升到92.0%。本工作开发了一种简便、通用的过滤膜抗菌功能化策略，为医疗领域各种新型抗菌过滤材料的设计和开发提供了新的方法。
Filtration membranes are widely applied in medical fields. However, these membranes are challenged by bacterial contamination in hospitals, which increases the risk of nosocomial infections. Thus, it is significant to develop antibacterial filtration membranes. In this work, an oxidated dextran (ODex)-based antibacterial coating was designed and constructed on microfiltration (MF) membranes and melt-blown fabrics. Polyhexamethylene guanidine (PHMG) was synthesized as an antibacterial agent, and was fixed by ODex onto filtration membranes. The functionalized MF membranes increased the filtration efficiency for E. coli from 20.9% to 99.9%, and improved the absorption ratio for endotoxin by 59.1%, while the water flow rate still remained as high as 5255 L (h m2)−1. Furthermore, the trapped bacteria were inactivated by the antibacterial coating. For the melt-blown fabrics, the aerosol filtration efficiency was increased from 74.6% to 81.0%, and the antibacterial efficiency was promoted to 92.0%. The present work developed a facile and universal antibacterial functionalization strategy for filtration membranes, which provided a new method for the design and development of various novel antibacterial filtration materials in the medical field.