Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion.
Muscarinic receptor density in the rat urinary bladder after denervation, hypertrophy and urinary diversion.
复制标题
去神经、肥大和尿流改道后大鼠膀胱中毒蕈碱受体密度。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
L. Malmberg
中科院分区：
文献类型：
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作者：
L. Nilvebrant;J. Ekström;L. Malmberg
Parasympathetic denervation of the urinary bladder results in supersensitivity to muscarinic agonists and in bladder hypertrophy. In the present study, the effects of denervation on the muscarinic receptors in the rat bladder were investigated, using a receptor binding technique with (-)3H-QNB as radioligand. The density of muscarinic receptors was increased in denervated, hypertrophied bladders but it was decreased, below that in control bladders, when the development of hypertrophy was prevented by urinary diversion. A decreased receptor density was also found in innervated bladders after urinary diversion, whereas the receptor density was unaffected by hypertrophy alone. Competition experiments with methacholine revealed no changes in the agonist binding properties of the receptors. When the present data are combined with those in previous functional studies, it seems unlikely that the muscarinic receptors in the bladder are involved in the development of supersensitivity. It is suggested that the density of muscarinic receptors in the bladder may be related to the bladder function.
DOI：
10.1016/s0022-5347(17)49045-8
发表时间：
1985
期刊：
The Journal of urology
影响因子：
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作者：
Malkowicz,SB;Atta,MA;Elbadawi,A;Wein,AJ;Levin,RM
通讯作者：
Levin,RM