The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics.
The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics.
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DOI：
10.1097/moh.0000000000000476
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发表时间：
2019-01
影响因子：
3.2
通讯作者：
Luo HR
中科院分区：
文献类型：
--
作者：
Zhang X;Guo R;Kambara H;Ma F;Luo HR
CXCR2 是免疫细胞迁移和招募的关键刺激物，尤其是中性粒细胞。减轻过度的中性粒细胞积聚和浸润可以防止炎症性疾病中的长期组织损伤。本综述重点介绍了我们对 CXCR2 在调节中性粒细胞迁移中的作用以及使用 CXCR2 拮抗剂治疗炎症性疾病的作用的最新进展。最近的研究为 CXCR2 信号如何调节健康和疾病中的造血细胞动员和功能提供了新的见解。我们还总结了感染和炎症期间的几种 CXCR2 调节机制，例如通过 Wip1、T-bet、P-选择素糖蛋白配体-1、粒细胞集落刺激因子和微生物组。此外，我们还提供了在实验室和临床试验中调查 CXCR2 阻断的研究的最新情况。中性粒细胞的稳态、迁移和募集必须受到精确调节。 CXCR2 信号通路是改变炎症性疾病中中性粒细胞动力学的潜在靶点。我们讨论了 CXCR2 拮抗剂最近用于控制炎症的临床应用。
CXCR2 is key stimulant of immune cell migration and recruitment, especially of neutrophils. Alleviating excessive neutrophil accumulation and infiltration could prevent prolonged tissue damage in inflammatory disorders. This review focuses on recent advances in our understanding of the role of CXCR2 in regulating neutrophil migration and the use of CXCR2 antagonists for therapeutic benefit in inflammatory disorders. Recent studies have provided new insights into how CXCR2 signaling regulates hematopoietic cell mobilization and function in both health and disease. We also summarize several CXCR2 regulatory mechanisms during infection and inflammation such as via Wip1, T-bet, P-selectin glycoprotein ligand-1, granulocyte-colony-stimulating factor, and microbiome. Moreover, we provide an update of studies investigating CXCR2 blockade in the laboratory and in clinical trials. Neutrophil homeostasis, migration, and recruitment must be precisely regulated. The CXCR2 signaling pathway is a potential target for modifying neutrophil dynamics in inflammatory disorders. We discuss the recent clinical use of CXCR2 antagonists for controlling inflammation.