Mononuclear Copper(II)-Superoxo Complexes that Mimic the Structure and Reactivity of the Active Centers of PHM and DβM
Mononuclear Copper(II)-Superoxo Complexes that Mimic the Structure and Reactivity of the Active Centers of PHM and DβM
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DOI：
10.1021/ja809464e
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发表时间：
2009-03-04
影响因子：
15
通讯作者：
Itoh, Shinobu
中科院分区：
文献类型：
--
作者：
Kunishita, Atsushi;Kubo, Minoru;Itoh, Shinobu
通过O-2与三齿配体L-X[1-(2-p-X-苯乙基)-5-(2-吡啶-2-基乙基)-1,5-二氮杂环辛烷负载的铜(I)起始原料1(X)反应，得到具有三重态(S=1)基态的单核铜(II)-超氧配合物2(X)-OO中心点； X = CH3, H, NO2] 在各种溶剂中。超氧复合物 2(X)-OO 中心点模拟肽基甘氨酸 α-羟基化单加氧酶和多巴胺 β-单加氧酶的结构[具有末端 (eta(1)) 结合的 O-2（中心点-）的四面体几何形状]和脂肪族 C-H 键活化化学。
Mononuclear copper (II)-superoxo complexes 2(X)-OO center dot having triplet (S = 1) ground states were obtained via reaction Of O-2 with the copper(I) starting materials 1(X) supported by tridentate tigands L-X [1-(2-p-X-phenethyl)-5-(2-pyridin-2-ylethyl)-1,5-diazacyclooctane; X = CH3, H, NO2] in various solvents. The superoxo complexes 2(X)-OO center dot mimic the structure [tetrahedral geometry with an end-on (eta(1))-bound O-2(center dot-)] and the aliphatic C-H bond activation chemistry of peptidylglycine alpha-hydroxylating monooxygenase and dopamine beta-monooxygenase.