Air pollution and multiple acute respiratory outcomes
Air pollution and multiple acute respiratory outcomes
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DOI：
10.1183/09031936.00128712
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发表时间：
2013-08-01
影响因子：
24.3
通讯作者：
Forastiere, Francesco
中科院分区：
文献类型：
--
作者：
Faustini, Annunziata;Stafoggia, Massimo;Forastiere, Francesco
空气污染物对呼吸道疾病死亡率和发病率的短期影响一直有报道，但通常是单独研究。为了更全面地评估空气污染的影响，我们研究了因呼吸系统疾病住院和院外呼吸系统死亡的情况。从2001年到2005年，在意大利六个城市进行了一项时间分层病例交叉研究。每日颗粒物（50%截止空气动力学直径为10 μ m的颗粒物（PM10））和二氧化氮（NO2）与呼吸系统疾病住院的关系（n=100 690），慢性阻塞性肺疾病（COPD）（n=38 577），COPD患者中下呼吸道感染（LRTI）（n=9886）和院外呼吸道死亡（n=5490）的估计年龄> 35年。对于PM10增加10 μ g.m（-3），我们发现，呼吸系统疾病住院率立即增加0.59%（滞后0-1天），COPD增加0.67%; LRTI住院率增加1.91%持续时间更长（滞后0-3天），呼吸系统死亡率增加3.95%持续6天。NO_2的作用较强，持续时间较长（滞后0-5天）。年龄、性别和既往缺血性心脏病是不同结果的影响因素。分析多个呼吸事件而不是单个呼吸事件显示出更强的空气污染影响。污染物增加与因呼吸道疾病住院或死亡率之间的时间关系各不相同。
Short-term effects of air pollutants on respiratory mortality and morbidity have been consistently reported but usually studied separately. To more completely assess air pollution effects, we studied hospitalisations for respiratory diseases together with out-of-hospital respiratory deaths.A time-stratified case-crossover study was carried out in six Italian cities from 2001 to 2005. Daily particulate matter (particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM10)) and nitrogen dioxide (NO2) associations with hospitalisations for respiratory diseases (n=100 690), chronic obstructive pulmonary disease (COPD) (n=38 577), lower respiratory tract infections (LRTI) among COPD patients (n=9886) and out-of-hospital respiratory deaths (n=5490) were estimated for residents aged >= 35 years.For an increase of 10 mu g.m(-3) in PM10, we found., an immediate 0.59% (lag 0-1 days) increase in hospitalisations for respiratory diseases and a 0.67% increase for COPD; the 1.91% increase in LRTI hospitalisations lasted longer (lag 0-3 days) and the 3.95% increase in respiratory mortality lasted 6 days. Effects of NO2 were stronger and lasted longer (lag 0-5 days). Age, sex and previous ischaemic heart disease acted as effect modifiers for different outcomes.Analysing multiple rather than single respiratory events shows stronger air pollution effects. The temporal relationship between the pollutant increases and hospitalisations or mortality for respiratory diseases differs.