Estrogenic biological activity and underlying molecular mechanisms of green tea constituents
Estrogenic biological activity and underlying molecular mechanisms of green tea constituents
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DOI：
10.1016/j.tifs.2019.11.014
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发表时间：
2020
影响因子：
15.3
通讯作者：
R. Kiyama
中科院分区：
文献类型：
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作者：
R. Kiyama
背景绿茶是由茶树山茶（Camellia sinensis）未经发酵而制成的，并且含有与促进健康作用（例如生理、免疫、神经和心理作用）以及对疾病（例如癌症、心血管疾病和糖尿病）的保护作用相关的特征成分。儿茶素类，如儿茶素、表儿茶素、表没食子儿茶素、表儿茶素-3-O-没食子酸酯和表没食子儿茶素-3-O-没食子酸酯，以及其它绿色茶成分，如花青素、黄烷-3-醇、黄酮醇、酚酸/缩酚酸和咖啡因/维生素，通过与特定蛋白质和信号通路的相互作用，与许多生物活性和细胞信号传导相关。范围和方法在由本论文通过文献检索，对绿色茶的主要成分、雌激素作用进行了研究，并通过动物实验、细胞实验、配体结合实验、蛋白质实验、转录实验、酵母双杂交实验等方法对绿茶的雌激素活性进行了评价。此外，健康益处，如骨保护/骨再生、心脏保护和神经保护，已经被报道为绿色茶成分的雌激素活性的潜在应用，而它们的抗雌激素活性已经与癌症治疗和化学预防相关联地被讨论。关于其混合雌激素/抗雌激素/非雌激素和双相活性以及相关毒性的有争议的结果需要进一步详细的研究来阐明其益处和风险。
BackgroundGreen tea is produced from the tea plantCamellia sinensiswithout fermentation, and contains characteristic constituents, which are associated with health-promoting effects such as physiological, immunological, neurological and psychological effects, and protective effects against diseases, such as cancer, cardiovascular diseases and diabetes. Catechins, such as catechin, epicatechin, epigallocatechin, epicatechin-3-O-gallate and epigallocatechin-3-O-gallate, and other green tea constituents, such as anthocyanidins, flavan-3-ols, flavonols, phenolic acids/depsides and caffeine/vitamins, are associated with many biological activities and cell signaling through interactions with specific proteins and signaling pathways.Scope and approachAmong the activities and pathways induced or mediated by green tea constituents, estrogen action was focused on through a comprehensive literature search.Key findings and conclusionsEstrogenic activity was evaluated by animal tests, cell assay, ligand-binding assay, protein assay, reporter-gene assay, transcription assay and yeast two-hybrid assay. Furthermore, health benefits, such as bone protection/bone regeneration, cardioprotection and neuroprotection, have been reported as the potential applications of the estrogenic activity of green tea constituents, whereas their anti-estrogenic activity has been discussed in association with cancer treatment and chemoprevention. Controversial results about their mixed estrogenic/anti-estrogenic/non-estrogenic and biphasic activity, and associated toxicity require further detailed studies to clarify the benefits and risks.