Fetal femur length is influenced by maternal dairy intake in pregnant African American adolescents
Fetal femur length is influenced by maternal dairy intake in pregnant African American adolescents
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DOI：
10.1093/ajcn/77.5.1248
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发表时间：
2003-05-01
影响因子：
7.1
通讯作者：
Witter, FR
中科院分区：
文献类型：
--
作者：
Chang, SC;O'Brien, KO;Witter, FR
背景：怀孕的青少年可能会与他们的发育中的胎儿争夺最佳骨矿化所需的营养。目的：本研究的目的是确定怀孕的非洲裔美国青少年在进入产前护理时，母亲摄入乳制品对怀孕20至34周的胎儿股骨发育的影响。设计：对1990至2000年间在市中心一家妇产科诊所接受护理的1120名非洲裔美国青少年(小于或等于17岁)进行了10年回顾图表回顾。在控制胎龄、双顶径、母亲的年龄和身高以及孕前体重指数后，使用广义多元线性回归模型来分析胎儿股骨长度的显著决定因素。根据24小时饮食回顾和食物频率问卷，在进入产前护理时估计乳制品的摄入量。结果：在这些平均年龄(+/-SD)为15.9+/-1.1岁(范围：12.7-17.9岁)的受试者中，在调整了胎龄、双顶径、孕妇年龄和身高以及孕前体重指数后，乳制品摄入量对胎儿股骨的生长有显著的正向影响(P=0.001，R2=0.97)。乳制品摄入量最低组(2份/d)胎儿股骨长度显著低于乳制品摄入量最高组(3份/d)，中度乳制品摄入量组(2-3份/d；P=0.089)呈剂量-反应关系。结论：孕期青少年摄入乳制品2份/d可能通过限制胎儿钙摄入量对胎儿骨骼发育产生负面影响。
Background: Pregnant adolescents may compete with their developing fetuses for the nutrients required for optimal bone mineralization.Objective: The objective of this study was to determine the effect in pregnant African American adolescents of maternal dairy intake at entry into prenatal care on fetal femur development between 20 and 34 wk of gestation.Design: A 10-y retrospective chart review was carried out in 1120 pregnant African American adolescents (less than or equal to 17 y of age) who had received care at an inner-city maternity clinic between 1990 and 2000. Generalized multiple linear regression models were used to address significant determinants of fetal femur length after control for gestational age, biparietal diameter, maternal age and height, and prepregnancy body mass index. Dairy intake was estimated at entry into prenatal care on the basis of 24-h dietary recall and a food-frequency questionnaire. Data from 350 subjects, for whom data on all variables were available, were included in the model.Results: In these pregnant adolescents with a mean (+/- SD) age of 15.9 +/- 1.1 y (range: 12.7-17.9 y), dairy intake had a significant positive effect on fetal femur growth after adjustment for gestational age, biparietal diameter, maternal age and height, and prepregnancy body mass index (P = 0.001, R-2 = 0.97). Fetal femur length was significantly lower in the lowest dairy-intake group (< 2 servings/d) than in the highest dairy-intake group (> 3 servings/d), and a dose-response relation was suggested in the intermediate dairy-intake group (2-3 servings/d; P = 0.089).Conclusion: These data suggest that consumption of < 2 servings of dairy products/d by pregnant adolescents may negatively affect fetal bone development by limiting the amount of calcium provided to the fetus.