Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.
Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis.
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DOI：
10.1016/j.jneuroim.2016.02.009
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发表时间：
2016-04-15
影响因子：
3.3
通讯作者：
Offner H
中科院分区：
文献类型：
--
作者：
Benedek G;Zhang J;Bodhankar S;Nguyen H;Kent G;Jordan K;Manning D;Vandenbark AA;Offner H
性激素促进多发性硬化症的免疫调节作用。本研究评估了实验性自身免疫性脑脊髓炎（EAE）期间雌激素对调节性B细胞和常驻中枢神经系统小胶质细胞的影响。在此，我们证明了雌激素依赖性诱导多种调节性B细胞标记物，指示IL-10依赖性和IFN-γ依赖性途径。此外，EAE小鼠的雌激素预处理虽然抑制了促炎细胞向中枢神经系统的浸润，但增加了调节性B细胞和M2小胶质细胞的频率。我们的研究表明，雌激素在EAE过程中对调节性B细胞的发育有广泛的影响，从而促进神经保护。
Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study evaluated estrogen effects on regulatory B cells and resident CNS microglia during experimental autoimmune encephalomyelitis (EAE). Herein, we demonstrate an estrogen-dependent induction of multiple regulatory B cell markers indicative of IL-10 dependent as well as IFN-γ dependent pathways. Moreover, although estrogen pretreatment of EAE mice inhibited the infiltration of pro-inflammatory cells into the CNS, it enhanced the frequency of regulatory B cells and M2 microglia. Our study suggests that estrogen has a broad effect on the development of regulatory B cells during EAE, which in turn could promote neuroprotection.