The influences of different spatial resolutions on the characteristics of T2 relaxation times in articular cartilage: A coarse-graining study of the microscopic magnetic resonance imaging data.
The influences of different spatial resolutions on the characteristics of T2 relaxation times in articular cartilage: A coarse-graining study of the microscopic magnetic resonance imaging data.
复制标题
不同空间分辨率对关节软骨T2弛豫时间特征的影响：显微磁共振成像数据的粗粒度研究。
DOI：
10.1002/jemt.22694
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发表时间：
2016
影响因子：
2.5
通讯作者：
Xia,Yang
中科院分区：
文献类型：
--
作者：
Zhuang,Zhiguo;Lee,JiHyun;Badar,Farid;Xu,Jianrong;Xia,Yang
通过分析犬不同胫骨位置软骨的显微磁共振成像(µMRI)T2数据，探讨空间分辨率和像素位置对T2对骨关节炎(OA)敏感性的影响。我们调查了五个实验因素：不准确的像素位置、不同的像素分辨率、磁场中不同的标本方向、胫骨表面的地形变化以及不同的OA分期。在这项分析中发现了一些重要的趋势，这表明T2的变化对我们检测OA的能力产生了微妙但实质性的影响。特别是，定位软骨像素的任何偏差都可能导致软骨表面附近的值不稳定。在所有分辨率下，几乎任何两个对照组之间的T2值在半月板覆盖和未覆盖区域都有显著差异，这也表明了OA退化阶段之间的交互作用。这一多分辨率项目应该有助于提高MRI对软骨退变的检测灵敏度。技术资源。2016年79：754-765。©2016 Wiley期刊，Inc.
Microscopic magnetic resonance imaging (µMRI) T2 data from canine cartilage at different tibial locations were analyzed to investigate the influences of spatial resolution and pixel position on the T2 sensitivity to osteoarthritis (OA). Five experimental factors were investigated: inaccurate pixel position, different pixel resolutions, different specimen orientations in the magnetic field, topographical variations over the tibial surface, and different OA stages. A number of significant trends were identified in this analysis, which shows the subtle but substantial influences to our abilities of detecting OA due to T2 changes. In particular, any deviation in locating the cartilage pixels may result in erratic values near the cartilage surface. Significant differences were found in T2 values between nearly any two comparison‐groups under all resolutions both in the meniscus‐covered and ‐uncovered areas, which were also showed interaction between the OA degradation stages. This multiresolution project should help to improve the detection sensitivities of MRI toward cartilage degeneration.Microsc. Res. Tech. 79:754–765, 2016. © 2016 Wiley Periodicals, Inc.