THE ORIGIN OF SUBSTANCE-P IN THE RAT SUB-MANDIBULAR GLAND AND ITS MAJOR DUCT
THE ORIGIN OF SUBSTANCE-P IN THE RAT SUB-MANDIBULAR GLAND AND ITS MAJOR DUCT
复制标题
DOI：
10.1016/0006-8993(82)90400-0
复制
发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
EMSON, PC
中科院分区：
文献类型：
--
作者：
GOEDERT, M;NAGY, JI;EMSON, PC
本文对大鼠颌下腺及其主管内P物质样免疫反应的来源进行了研究。损毁下颌下腺的交感神经、节前、节后和感觉神经支配，或用神经毒素辣椒素治疗，仅导致腺体P物质样免疫反应性含量轻微而不明显的下降。相反，去感觉神经和辣椒素治疗均显著减少颌下腺主管中P物质样免疫反应物质的含量。导管的神经支配显然是感觉性的，而腺体本身的P物质样免疫反应似乎是内在的。
The origin of the substance P-like immunoreactivity in the rat submandibular gland and its major duct was investigated. Lesions severing the sympathetic, pre- and postganglionic and sensory innervation of the submandibular gland, or treatment with the neurotoxin capsaicin, produced only a small non-significant decrease in the substance P-like immunoreactivity content of the gland. In contrast, both sensory denervation and capsaicin treatment produced a substantial decrease in the content of substance P-like immunoreactivity in the major duct of the submandibular gland. The duct innervation is clearly of sensory origin, while the substance P-like immunoreactivity of the gland itself appears to be intrinsic.