Cholestasis in Infancy
Cholestasis in Infancy
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DOI：
10.3928/19382359-20161118-01
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发表时间：
2016-12-01
期刊：
影响因子：
1.1
通讯作者：
Azzam, Ruba K.
中科院分区：
文献类型：
--
作者：
Andrianov, Melissa G.;Azzam, Ruba K.
黄疸是所有年龄组肝胆疾病的主要表现。黄疸是出生后前2周的常见发现，发生在2.4%至15%的新生儿中。新生儿肝脏对胆汁淤积的敏感性增加，发病率范围为1/2，500至1/5，000活产。病因各异，但最常见的是胆道闭锁。2004年，北美儿科胃肠病学、肝病学和营养学会发布了胆汁淤积评估指南，明确指出任何黄疸持续超过2周的婴儿（母乳喂养的婴儿为3周，其他病史和体格检查正常）应使用分级血清胆红素水平进行评估。及时评估、诊断和干预对于优化及时干预和改善临床结局至关重要。本文讨论了婴儿胆汁淤积症的病因、诊断和评价。
Jaundice is a key manifestation of hepatobiliary disease in all age groups. Jaundice is a common finding in the first 2 weeks after birth,, occurring in 2.4% to 15% of newborns. The neonatal liver is at increased susceptibility to cholestasis, with an incidence ranging from 1 in 2,500 to 1 in 5,000 live births. Etiologies vary, but the most common is biliary atresia. In 2004, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition published guidelines for the evaluation of cholestasis that clearly stated any infant with jaundice persisting beyond age 2 weeks (3 weeks in breast-fed infants with an otherwise normal history and physical examination) should be evaluated with a fractionated serum bilirubin level. Prompt evaluation, diagnosis, and intervention are vital to optimize timely intervention and improve clinical outcomes. This article discusses the etiology, diagnosis and evaluation of cholestatis in infants.