Mechanistic insights and implications of FOXO‐SNAI interplay
Mechanistic insights and implications of FOXO‐SNAI interplay
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DOI：
10.1002/bies.202200070
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发表时间：
2022-07
期刊：
影响因子：
4
通讯作者：
Xiaowei Guo;Chenxi Wu;Yu Pan;Xiaojie Zhu;Kai Peng;Xianjue Ma;L. Xue
中科院分区：
文献类型：
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作者：
Xiaowei Guo;Chenxi Wu;Yu Pan;Xiaojie Zhu;Kai Peng;Xianjue Ma;L. Xue
自噬促进健康和疾病，这取决于组织类型和遗传背景，但调控机制仍不完全清楚。我们最近的出版物揭示了自噬中连贯的FOXO‐SNAI前馈回路，这在果蝇到人类的进化中是保守的。此外，DNA结合在核质穿梭蛋白的胞内定位中起着重要作用。基于这些发现，我们在本文中进一步整合了自噬中FOXO-SNAI调控相互作用的机制见解，并揭示了FOXO诱导的自噬与疾病中SNAI的潜在联系。此外，DNA保留机制对转录因子核定位的普遍性进行了广泛的讨论，并提供了FOXO‐SNAI前馈环可能调控的更多功能。阐明这些未解决的范式将扩大对FOXO‐SNAI相互作用的理解，并促进针对疾病中FOXO‐SNAI轴的新疗法的开发。
Autophagy promotes both health and disease, depending on tissue types and genetic contexts, yet the regulatory mechanism remain incompletely understood. Our recent publication has uncovered a coherent FOXO‐SNAI feed‐forward loop in autophagy, which is evolutionarily conserved from Drosophila to human. In addition, it's revealed that DNA binding plays a critical role in intracellular localization of nucleocytoplasmic shuttling proteins. Based on these findings, herein we further integrate mechanistic insights of FOXO‐SNAI regulatory interplay in autophagy and unravel the potential link of FOXO‐induced autophagy with SNAI in diseases. Besides, the generality of DNA‐retention mechanism on transcription factor nuclear localization is illustrated with wide‐ranging discussion, and more functions potentially regulated by FOXO‐SNAI feedforward loop are provided. Elucidation of these unsolved paradigms will expand the understanding of FOXO‐SNAI interplay and facilitate the development of new therapeutics targeting FOXO‐SNAI axis in diseases.