Mechanistic interrelationships between two superfamilies: the steroid/retinoid receptors and transforming growth factor-beta.
Mechanistic interrelationships between two superfamilies: the steroid/retinoid receptors and transforming growth factor-beta.
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两个超家族之间的机制相互关系：类固醇/视黄醇受体和转化生长因子-β。
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
M. Sporn
中科院分区：
文献类型：
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作者：
A. Roberts;M. Sporn
内分泌学和肽生长因子领域不再能够独立研究，关于激素和生长因子作用模式的假设也不能受到过时的经典定义的限制。尽管关于类固醇/类维生素A诱导TGF-β活性的机制、关于特定核受体的参与以及关于调节类固醇/类维生素A对TGF-β的各种同工型的不同作用的因素还有很多有待了解，但很明显，对这两个多功能效应子超家族之间相互关系的识别预示着发现控制细胞增殖和分化的潜在调节事件的新时代。
The fields of endocrinology and peptide growth factors can no longer be studied independently, nor can hypotheses about the modes of action of hormones and growth factors be constrained by outmoded classic definitions. Although much is still to be learned about the mechanisms of induction of TGF-beta activity by steroids/retinoids, about the involvement of specific nuclear receptors and about the factors regulating the differential effects of steroids/retinoids on the various isoforms of TGF-beta, it is clear that the identification of the interrelationships between these two superfamilies of multi-functional effectors has heralded a new era of discovery of the underlying regulatory events controlling cellular proliferation and differentiation.