SELECTIVE AGONISTS AT NK3 TACHYKININ RECEPTORS INHIBIT ALCOHOL INTAKE IN SARDINIAN ALCOHOL-PREFERRING RATS
SELECTIVE AGONISTS AT NK3 TACHYKININ RECEPTORS INHIBIT ALCOHOL INTAKE IN SARDINIAN ALCOHOL-PREFERRING RATS
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DOI：
10.1016/0361-9230(94)90050-7
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发表时间：
1994-01-01
影响因子：
3.8
通讯作者：
MASSI, M
中科院分区：
文献类型：
--
作者：
CICCOCIOPPO, R;PANOCKA, I;MASSI, M
本研究评估了对不同神经激肽（NK）受体选择性的速激肽激动剂对遗传选择的撒丁岛嗜酒大鼠酒精摄入量的影响。速激肽在进入液体之前通过脑室内注射。在给予水和8%乙醇2 h/d的大鼠中，NK3选择性激动剂[Asp(5,6),MePhe(8)] P物质（5-11），Suc-[Asp(6),MePhe(8)] P物质（6-11）和[MePhe(7)]神经动素B显著抑制酒精摄入。NK1选择性激动剂[Sar(9),Met(O-2)11] P物质和NK2选择性激动剂GR 64349没有减少酒精摄入量。在抑制酒精摄入的剂量下，NK3激动剂没有改变水的摄入量；总液体摄入量仅在500 ng/rat [Asp(5,6),MePhe(8)] P物质（5-11）后显著减少。当大鼠被给予更长时间的液体（8%酒精2小时，但水4小时），再次，NK3激动剂抑制酒精摄入量，但不是总液体摄入量。此外，当没有酒精时，NK3激动剂不会改变缺食大鼠的固体食物摄入量，也不会改变缺水大鼠的水摄入量。这些发现表明，NK3激动剂抑制撒丁岛嗜酒大鼠的酒精摄入，其作用具有行为选择性。他们还认为中枢NK3受体可能参与了大鼠的酒精摄入控制。
The present study evaluated the effect of tachykinin agonists, selective for different neurokinin (NK) receptors, on alcohol intake in genetically selected, Sardinian alcohol-preferring rats. Tachykinins were given by intracerebroventricular injection just before access to fluids. In rats offered both water and 8% ethanol 2 h/day, the NK3 selective agonists [Asp(5,6),MePhe(8)]substance P(5-11), Suc-[Asp(6),MePhe(8)]substance P(6-11), and [MePhe(7)]neurokinin B markedly suppressed alcohol intake. The NK1 selective agonist [Sar(9),Met(O-2)11]substance P and the NK2 selective agonist GR 64349 did not reduce alcohol intake. At doses that inhibited alcohol intake, the NK3 agonists did not modify water intake; total fluid intake was significantly reduced only following 500 ng/rat of [Asp(5,6),MePhe(8)]substance P(5-11). When rats were given a longer access to fluids (8% alcohol for 2 h, but water for 4 h), again, NK3 agonists suppressed alcohol intake, but not total fluid intake. Moreover, NK3 agonists did not modify solid food intake in food-deprived rats, nor water intake in water-deprived rats, when alcohol was not available. These findings indicate that NK3 agonists inhibit alcohol intake in Sardinian alcohol-preferring rats and that their effect is behaviorally selective. They also suggest that central NK3 receptors may be involved in alcohol intake control in rats.