Multiple sclerosis in the Orkney and Shetland Islands. IV: Viral antibody titres and viral infections.
Multiple sclerosis in the Orkney and Shetland Islands. IV: Viral antibody titres and viral infections.
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奥克尼群岛和设得兰群岛的多发性硬化症。
DOI：
10.1136/jech.34.4.258
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发表时间：
1980
影响因子：
6.3
通讯作者：
Prenney
中科院分区：
文献类型：
--
作者：
D. Poskanzer;J. Sever;J. Sheridan;B. Lewis;Prenney
在奥克尼和设得兰群岛对多发性硬化症患者进行了17种病毒抗体效价的对照血清学调查。与两个对照组相比，患者中没有一致的抗体滴度水平升高或抗体存在的模式。由于这些岛屿与外界隔绝，儿童感染包括麻疹在内的常见疾病的平均年龄比欧洲和美利坚合众国的居民要大得多。患者发生水痘的年龄始终低于对照组。值得注意的是，有6名患者在MS发病后出现麻疹。这项研究未能证实MS病因学中检测到的任何病毒。
A controlled serologic survey of antibody titres to 17 viruses was undertaken in multiple sclerosis patients in the Orkney and Shetland Islands. No consistent pattern of elevated antibody titre levels or the presence of antibody was noted in patients compared with two control groups. Because of the isolation of these islands, the mean age at acquisition of common childhood infections, including measles, was considerably older than that of inhabitants of Europe and the United States of America. The age of occurrence of varicella was consistently younger in patients than in controls. Of note is the fact that six patients had measles after the onset of MS. This study failed to incriminate any of the viruses tested in the aetiology of MS.