Clade replacements in dengue virus serotypes 1 and 3 are associated with changing serotype prevalence
Clade replacements in dengue virus serotypes 1 and 3 are associated with changing serotype prevalence
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DOI：
10.1128/jvi.79.24.15123-15130.2005
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发表时间：
2005-12-01
影响因子：
5.4
通讯作者：
Holmes, EC
中科院分区：
文献类型：
--
作者：
Zhang, CL;Mammen, MP;Holmes, EC
登革病毒（DENY）进化的特点是系统发育树，具有强大的时间结构，由分支频率的急剧变化打断。为了确定这些大规模系统发育模式的原因，我们研究了DENY血清型1（DENY-1）和DENV-3在泰国的进化历史，在那里基因序列和流行病学数据在30年内相对丰富。我们发现了两种血清型中病毒进化枝周转的证据，最明显的是在DENV-1中，其中在20世纪90年代中期在基因型I中发生了主要的进化枝替换事件。此外，当将该进化枝替换事件置于泰国血清型流行率变化的背景下时，出现了惊人的模式; DENV-1进化枝多样性的增加与该血清型丰度的增加和DENV-4流行率的伴随降低相关，而进化枝替换与DENV-1流行率的下降和DENV-4的上升相关。我们假设，在相对血清型丰富的情况下，型内遗传多样性会发生，并且替换事件可能是由于对交叉反应性免疫反应的易感性差异而导致的。
The evolution of dengue virus (DENY) is characterized by phylogenetic trees that have a strong temporal structure punctuated by dramatic changes in clade frequency. To determine the cause of these large-scale phylogenetic patterns, we examined the evolutionary history of DENY serotype 1 (DENY-1) and DENV-3 in Thailand, where gene sequence and epidemiological data are relatively abundant over a 30-year period. We found evidence for the turnover of viral clades in both serotypes, most notably in DENV-1, where a major clade replacement event took place in genotype I during the mid-1990s. Further, when this clade replacement event was placed in the context of changes in serotype prevalence in Thailand, a striking pattern emerged; an increase in DENV-1 clade diversity was associated with an increase in the abundance of this serotype and a concomitant decrease in DENV-4 prevalence, while clade replacement was associated with a decline in DENV-1 prevalence and a rise of DENV-4. We postulate that intraserotypic genetic diversification proceeds at times of relative serotype abundance and that replacement events can result from differential susceptibility to cross-reactive immune responses.