From Guard to Decoy: A new model for perception of plant pathogen effectors
From Guard to Decoy: A new model for perception of plant pathogen effectors
复制标题
DOI：
10.1105/tpc.108.060194
复制
发表时间：
2008-08-01
期刊：
影响因子：
11.6
通讯作者：
Kamoun, Sophien
中科院分区：
文献类型：
--
作者：
van der Hoorn, Renier A. L.;Kamoun, Sophien
抗病性守卫模型假设植物抗性蛋白通过监测（守卫）其相应病原体效应子的目标来发挥作用。然而，我们假设，在具有抗性（R）基因多态性的植物群体中，受保护的效应子靶标在进化上是不稳定的。根据 R 基因的缺失或存在，受保护的效应器目标会受到相反的选择力的影响（1）以逃避效应器的操纵（较弱的相互作用）和（2）以改善效应器的感知（更强的相互作用）。效应器目标基因的复制或目标模拟物的独立进化可以放松进化限制并产生仅参与效应器感知的诱饵。涉及 Pto、Bs3、RCR3 和 RIN4 的四种不同的效应器感知案例越来越支持这种诱饵模型。我们讨论了警卫模型和诱饵模型及其变体之间的差异，假设诱饵可能如何进化，并提出挑战诱饵模型的方法。
The Guard Model for disease resistance postulates that plant resistance proteins act by monitoring ( guarding) the target of their corresponding pathogen effector. We posit, however, that guarded effector targets are evolutionarily unstable in plant populations polymorphic for resistance ( R) genes. Depending on the absence or presence of the R gene, guarded effector targets are subject to opposing selection forces ( 1) to evade manipulation by effectors ( weaker interaction) and ( 2) to improve perception of effectors ( stronger interaction). Duplication of the effector target gene or independent evolution of a target mimic could relax evolutionary constraints and result in a decoy that would be solely involved in effector perception. There is growing support for this Decoy Model from four diverse cases of effector perception involving Pto, Bs3, RCR3, and RIN4. We discuss the differences between the Guard and Decoy Models and their variants, hypothesize how decoys might have evolved, and suggest ways to challenge the Decoy Model.