Sexual Functioning in Adolescents With Major Depressive Disorder.
Sexual Functioning in Adolescents With Major Depressive Disorder.
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DOI：
10.4088/jcp.15m09840
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发表时间：
2016-07
期刊：
影响因子：
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通讯作者：
Calarge CA
中科院分区：
文献类型：
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作者：
Deumic E;Butcher BD;Clayton AD;Dindo LN;Burns TL;Calarge CA
本研究旨在探讨青少年抑郁症患者的性功能。在2010年9月至2014年3月期间，235名年龄在15至20岁之间、未接受药物治疗或在开始抗抑郁治疗一个月内的参与者完成了贝克抑郁（BDI）和焦虑量表（BAI）以及性功能变化问卷（CSFQ）。根据DSM-IV-TR，他们也被评估是否存在重度抑郁发作（MDE）。学生t检验和卡方检验分别用于比较有和没有MDE的参与者的连续变量和分类变量。多变量线性回归分析检验了抑郁与性功能之间的关系。在控制了年龄、女性性别、抗抑郁药使用和广泛性焦虑障碍的存在后，MDE的存在与CSFQ总体得分以及欲望、觉醒和性高潮亚量表得分较低有关。抗抑郁药与性功能无关，无论是在总体样本中还是在MDE患者中。BDI项目与情感症状有关，而不是那些涉及神经植物或认知功能的项目，解释了抑郁症和性功能低下之间的联系。此外，BDI分数越高，男性在CSFQ总分和欲望分量表上的下降幅度都比女性大。焦虑与性功能没有显著关联。老年青少年的MDE与性功能低下有关，尤其是男性。这似乎与情感症状最相关。这种损伤对未来性功能的潜在影响值得进一步研究。
This study aims to examine sexual functioning in adolescents with depression. Between 09/2010 and 03/2014, 235 participants who were between 15 and 20 years old and were unmedicated or within one month of beginning antidepressant treatment completed the Beck Depression (BDI) and Anxiety Inventories (BAI) and the Changes in Sexual Functioning Questionnaire (CSFQ). They were also assessed to establish the presence of a major depressive episode (MDE), following the DSM-IV-TR. The Student’s t test and chi-square test were used to compare continuous and categorical variables, respectively, across participants with vs. without MDE. Multivariable linear regression analysis examined the association between depression and sexual functioning. After controlling for age, female sex, antidepressant use, and the presence of generalized anxiety disorder, the presence of MDE was associated with a lower score on the CSFQ overall as well as on its desire, arousal, and orgasm subscales. Antidepressants were not associated with sexual functioning neither in the sample overall nor in those with MDE. BDI items related to affective symptoms, rather than those tapping into neurovegetative or cognitive functioning, accounted for the association between depression and lower sexual functioning. Furthermore, with higher BDI scores, males exhibited a steeper decline than females in both the CSFQ total score as well as in the desire subscale. Anxiety was not significantly associated with sexual functioning. MDE in older adolescents is associated with lower sexual functioning, particularly in males. This appears most related to affective symptoms. The potential impact of such impairment on future sexual functioning deserves further examination.