Cancer stem cell and stromal microenvironment.

Cancer stem cell and stromal microenvironment.
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DOI：
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发表时间：
2013
期刊：
The Ochsner journal
影响因子：
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通讯作者：
Li Li-Li;J. Cole;D. Margolin
Li Li-Li;J. Cole;D. Margolin
中科院分区：
其他
文献类型：
--
作者：
Li Li-Li;J. Cole;D. Margolin

文献摘要

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背景：化疗耐药和局部复发或远处器官转移是癌症死亡的主要原因。传统的癌症治疗方法并不能始终如一地预防癌症复发。方法研究肿瘤干细胞和肿瘤微环境，特别是淋巴结间质微环境在2种典型肿瘤（结直肠癌和滤泡性淋巴瘤）耐药、转移和复发中的关键作用。结论：我们认为化疗药物联合靶向治疗，如基质/癌症干细胞信号靶向治疗，可以有效地减少癌症复发。
BACKGROUND Chemotherapeutic resistance and local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional cancer treatments do not consistently prevent cancer recurrence. METHODS We illustrate the key roles that cancer stem cells and the tumor microenvironment-particularly the lymph node stromal microenvironment-play in tumor drug resistance, metastasis, and recurrence in 2 representative cancers: colorectal cancer and follicular lymphoma. CONCLUSION We believe that combination treatment with chemotherapeutic agents in conjunction with targeted therapies, such as stromal/cancer stem cell signaling-targeted therapy, may effectively minimize cancer recurrence.