In vivo Percutaneous Absorptiometry by a Laser Photoacoustic Method Using a Novel Open-Ended Cell Combined with Light Guide
In vivo Percutaneous Absorptiometry by a Laser Photoacoustic Method Using a Novel Open-Ended Cell Combined with Light Guide
复制标题
使用新型开放式细胞与光导相结合的激光光声体内经皮吸收测定法
DOI：
10.1051/jp4:19947105
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Sawada
中科院分区：
文献类型：
--
作者：
R. Takamoto;S. Yamamoto;R. Namba;M. Matsuoka;T. Sawada
利用一种新型的开放式光声池，发展了一种高灵敏度、高精度的激光光声方法。这种PA池是通过在PA池的样品室中处理光导的末端并通过在一端连接声学管而构建的，该声学管在一端被最佳地弯曲成直角。这种设计最大限度地减少了死体积，并提供了更大的测量灵活性。PA池的设计基于共振原理，允许PA池中的气体体积小于Helmholtz共振的气体体积。结果，新的PA细胞的灵敏度大约是传统PA细胞的10倍。在聚乙二醇载体中引入的吲哚美辛(IDM)软膏的灵敏度和重复性优于10次重复测量
A laser photoacoustic (PA) method with high sensitivity and accuracy using a novel open-ended PA cell was developed. This PA cell was constructed by processing the end of a light guide an the sample chamber of the PA cell and by attaching an acoustic pipe which was bent optimally to a right angle at one end. This design minimized the dead volume and provided more measurement flexibility. The PA cell design is based on the principle of a resonance permitting a smaller gas volume in the PA cell than that of Helmholtz resonance. As a result, the new PA cell sensitivity was about 10 times that of a conventional PA cell. The sensitivity and reproducibility for in situ PA measurement of an indomethacin (IDM) ointment introduced in a poly(ethylene glycol) vehicle were excellent over 10 repeated measurements