Targeting senescent cells and tumor therapy (Review).
Targeting senescent cells and tumor therapy (Review).
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DOI：
10.3892/ijmm.2020.4705
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发表时间：
2020-11
影响因子：
5.4
通讯作者：
Xu C
中科院分区：
文献类型：
--
作者：
Wang Z;Gao J;Liu H;Ohno Y;Xu C
细胞衰老是由细胞损伤积累引起的细胞周期抑制途径的激活引起的，细胞永久性地离开细胞周期。衰老细胞在细胞形态、转录、蛋白稳态、代谢等方面发生改变。同时，衰老细胞在体内具有抗凋亡能力，并在多个器官和组织中积累。衰老细胞能够激活炎症因子分泌途径，在组织内产生局部、非感染性炎症微环境，导致器官变性和衰老相关疾病的发生。最近发表的大量研究表明，从体内清除衰老细胞可以延缓各种衰老相关疾病的发生。因此，靶向杀伤衰老细胞可能在治疗各种衰老相关疾病方面具有重要的临床应用价值，旨在提高患者的寿命。本文综述了近年来在清除衰老细胞和各种抗衰老策略方面的研究进展。本文简要回顾了细胞衰老研究的历史，以及细胞衰老与肿瘤治疗的关系。此外，本文主要讨论了衰老细胞作为各种衰老相关疾病的治疗靶点的潜力，并对这一研究方向的局限性和未来前景进行了综述。
Cell senescence is caused by the activation of cell cycle inhibition pathways induced by an accumulation of cellular damage, where cells permanently leave the cell cycle. Senescent cells undergo changes in cell morphology, transcription, protein homeostasis, metabolism and other characteristic alterations. At the same time, senescent cells are able to resist apoptosis and accumulate in multiple organs and tissues in vivo. Senescent cells are capable of activating inflammatory factor secretion pathways, generating local, non-infectious inflammatory microenvironments within tissues, leading to organ degeneration and the development of aging-associated diseases. A large number of recently published studies have demonstrated that removing senescent cells from the body delays the occurrence of various aging-associated diseases. Therefore, the targeted killing of senescent cells potentially has important clinical applications in the treatment of various aging-associated diseases, aiming to improve the life span of patients. The present review summarizes recent progress that has been made in the field of senescent cell clearance and various anti-aging strategies. The history of cell senescence research is briefly reviewed, along with the association between cell senescence and tumor therapy. Furthermore, the potential of senescent cells to be used as therapeutic targets in various senescence-associated diseases is primarily discussed, and the limitations, as well as the future prospects of this line of research, are reviewed.
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DOI：
10.1098/rstb.2010.0291
发表时间：
2011-01-12
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Donate LE;Blasco MA
通讯作者：
Blasco MA
影响因子：
4.6
作者：
Liu S;Uppal H;Demaria M;Desprez PY;Campisi J;Kapahi P
通讯作者：
Kapahi P
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
--
作者：
Leontieva OV;Blagosklonny MV
通讯作者：
Blagosklonny MV
DOI：
10.1073/pnas.92.20.9363
发表时间：
1995-09-26
影响因子：
11.1
作者：
DIMRI, GP;LEE, XH;CAMPISI, J
通讯作者：
CAMPISI, J