LIMBIC SEIZURES INCREASE NEURONAL PRODUCTION OF MESSENGER-RNA FOR NERVE GROWTH-FACTOR
LIMBIC SEIZURES INCREASE NEURONAL PRODUCTION OF MESSENGER-RNA FOR NERVE GROWTH-FACTOR
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DOI：
10.1126/science.2549634
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发表时间：
1989-08-18
期刊：
影响因子：
56.9
通讯作者：
ISACKSON, PJ
中科院分区：
文献类型：
--
作者：
GALL, CM;ISACKSON, PJ
端脑神经元产生的神经生长因子（NGF）为基底前脑的胆碱能神经元提供关键的营养支持。原位杂交和核酸酶保护分析表明，边缘系统癫痫发作在癫痫发作后 1 小时内显着增加海马齿状回神经元中 NGF 信使 RNA 的数量，并在数小时后在广泛分布的副皮质和嗅觉前脑神经元中增加 NGF 信使 RNA 的数量。增加的信使RNA种类与.beta的转录本B的信使RNA无法区分。来自小鼠颌下腺的 NGF 亚基。因此，一种已知生长因子的表达受到异常生理活动的影响，这表明可以改变成人大脑神经元之间营养相互作用的一种途径。
Nerve growth factor (NGF) produced by telencephalic nerons provides critical trophic support for cholinergic neurons of the basal forebrain. In situ hybridization and nuclease protection analyses demonstrate that limbic seizures dramatically increase the amount of messenger RNA for NGF in the neurons of the hippocampal dentate gyrus within 1 hour of seizure onset and in broadly distributed eocortical and olfactory forebrain neurons some hours later. The increased messenger RNA species is indistinguishable from messenger RNA for transcript B of the .beta. subunit of NGF from mouse submandibular gland. Thus, the expression of a known growth factor is affected by unusual physiological activity, suggesting one route through which trophic interactions between neurons in adult brain can be modified.