Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5′-flanking region (−5229G/A) with bone mineral density
Association of a single nucleotide polymorphism in the lipoxygenase ALOX15 5′-flanking region (−5229G/A) with bone mineral density
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DOI：
10.1007/s00774-004-0588-x
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发表时间：
2004
影响因子：
3.3
通讯作者：
T. Urano;M. Shiraki;M. Fujita;T. Hosoi;H. Orimo;Y. Ouchi;S. Inoue
中科院分区：
文献类型：
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作者：
T. Urano;M. Shiraki;M. Fujita;T. Hosoi;H. Orimo;Y. Ouchi;S. Inoue
12/15-脂氧合酶基因Alox 15通过遗传学和基因组学的联合分析被确定为小鼠骨密度（BMD）的易感基因。在此，我们研究了骨密度和ALOX 15基因单核苷酸多态性之间的关系，以评估人类ALOX 15基因在绝经后骨质疏松症中的潜在参与。具体而言，我们研究了319名绝经后日本女性（66.7 ± 8.9岁，平均值±标准差）ALOX 155 ′侧翼区− 5299 G/A单核苷酸多态性与BMD之间的关系。我们发现携带至少一个变异A等位基因的受试者（GA + AA;n= 273）与无A等位基因的受试者相比，腰椎和全身骨密度的Z评分显著降低（GG;n= 46）（腰椎，−0.25 ± 1.34 vs 0.48 ± 1.70;P= 0.0014;全身，0.25 ± 1.01 vs 0.62 ± 1.11;P= 0.048）。这些结果表明，ALOX 15基因是绝经后妇女BMD的遗传决定因素之一。因此，该多态性可作为预测骨质疏松症风险的遗传标记物。
The 12/15-lipoxygenase geneAlox15has been identified as a susceptibility gene for bone mineral density (BMD) in mice through combined genetic and genomic analyses. Here we studied the association between bone mineral density and anALOX15gene single nucleotide polymorphism to assess the potential involvement of the humanALOX15gene in postmenopausal osteoporosis. Specifically, we examined the association between a single nucleotide polymorphism at −5299G/A in theALOX155′-flanking region with BMD in 319 postmenopausal Japanese women (66.7 ± 8.9 years, mean ± SD). We found that subjects bearing at least one variant A allele (GA + AA;n= 273) had significantly lowerZscores for lumbar spine and total body bone mineral density than did subjects with no A allele (GG;n= 46) (lumbar spine, −0.25 ± 1.34 versus 0.48 ± 1.70;P= 0.0014; total body, 0.25 ± 1.01 vs 0.62 ± 1.11;P= 0.048). These findings suggest that theALOX15gene is one of the genetic determinants of BMD in postmenopausal women. Accordingly, this polymorphism could be useful as a genetic marker for predicting the risk of osteoporosis.