Mast cells in health and disease.
Mast cells in health and disease.
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DOI：
10.1042/cs20100459
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发表时间：
2011-06
期刊：
影响因子：
6
通讯作者：
C. Weller;Sarah J. Collington;T. Williams;J. Lamb
中科院分区：
文献类型：
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作者：
C. Weller;Sarah J. Collington;T. Williams;J. Lamb
尽管肥大细胞早在100多年前就被发现，但在这段时间的大部分时间里，它们的功能几乎完全与过敏和过敏性疾病有关，在健康和疾病中几乎没有其他作用。mc缺陷小鼠的工程设计和植入这些缺乏受体或介质的mc小鼠，提高了我们对mc在体内作用的认识。现在我们知道，MCs在生理和疾病中都有非常广泛和多样的作用，这里将重点介绍去年的一些最新发现。MCs可以通过分泌促进伤口愈合和平衡以及与神经元相互作用的介质来帮助维持健康的生理机能。在了解mcc在防御病原体、识别病原体以及直接效应功能方面的功能方面取得了重大进展。可能发展最快的理解领域是MCs在从一些最常见的疾病到更晦涩的疾病的各种疾病的进展中的参与和贡献。
Although MCs (mast cells) were discovered over 100 years ago, for the majority of this time their function was linked almost exclusively to allergy and allergic disease with few other roles in health and disease. The engineering of MC-deficient mice and engraftment of these mice with MCs deficient in receptors or mediators has advanced our knowledge of the role of MCs in vivo. It is now known that MCs have very broad and varied roles in both physiology and disease which will be reviewed here with a focus on some of the most recent discoveries over the last year. MCs can aid in maintaining a healthy physiology by secreting mediators that promote wound healing and homoeostasis as well as interacting with neurons. Major developments have been made in understanding MC function in defence against pathogens, in recognition of pathogens as well as direct effector functions. Probably the most quickly developing area of understanding is the involvement and contribution MCs make in the progression of a variety of diseases from some of the most common diseases to the more obscure.