Life-phase specific induction and expression of rapid expulsion in rats suckling Trichinella spiralis-infected dams.
Life-phase specific induction and expression of rapid expulsion in rats suckling Trichinella spiralis-infected dams.
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发表时间：
1985-06
期刊：
影响因子：
6.4
通讯作者：
J. Appleton;D. McGregor
中科院分区：
文献类型：
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作者：
J. Appleton;D. McGregor
饲养前4周感染1000只旋毛虫肌肉幼虫的大鼠在2周龄时对200只旋毛虫肌肉幼虫具有免疫能力。免疫表现为24小时内消除75-99%的攻毒剂量。肠道蠕虫负荷在初始驱逐后没有显著下降。在感染后长达26周的三个繁殖周期中，受感染的水坝继续保护它们的后代。通过对寄生虫生命周期的非肠外阶段进行选择性免疫，幼崽获得了免疫力。药物终止性肠内感染的免疫是无效的，肠内免疫随后是肠外阶段。进一步分析表明，幼崽的快速驱逐依赖于接种NBL后恢复的成熟肌肉幼虫的数量。相比之下，在试验范围内，增加NBL的数量并没有提高相同水坝的排水量。
Rat dams infected with 1000 Trichinella spiralis muscle larvae, 4 weeks prior to breeding, provided their suckling offspring with immunity to challenge with 200 muscle larvae at 2 weeks of age. The immunity was expressed in the elimination of 75-99% of the challenge dose within 24 hr. The intestinal worm burden did not decline significantly after the initial expulsion. Infected dams continued to protect their offspring during three breeding cycles, for as long as 26 weeks after infection. Immunity was conferred upon pups by dams that had been selectively immunized with the parenteral phase of the parasite's life cycle. Immunization with a drug-terminated enteral infection was ineffective as was enteral immunization followed by the parenteral phase. Further analysis revealed that rapid expulsion by pups was dependent on the number of mature muscle larvae recovered from dams immunized with NBL. By comparison, the expulsive capacity of the same dams was not improved by increasing the numbers of NBL within the range tested.