Influence of audiogenic seizures on synaptic facilitation in mouse hippocampal slices is mediated by N-methyl-D-aspartate receptor.
Influence of audiogenic seizures on synaptic facilitation in mouse hippocampal slices is mediated by N-methyl-D-aspartate receptor.
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听源性癫痫发作对小鼠海马切片突触易化的影响是由 N-甲基-D-天冬氨酸受体介导的。
DOI：
10.1111/j.1528-1157.1993.tb02122.x
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发表时间：
1993
期刊：
影响因子：
5.6
通讯作者：
Seyfried,TN
中科院分区：
文献类型：
--
作者：
Wieraszko,A;Seyfried,TN
在DBA/2 J（D2）和C57 BL/6 J（B6）小鼠上研究了听源性癫痫发作（AGS）对突触易化的影响。AGS易感性在D2小鼠中是遗传的，但可以通过声激发在AGS抗性B6小鼠中获得。实验在从具有和不具有癫痫发作的D2和B6小鼠获得的海马切片上进行。在刺激Schaffer结肠后评价长时程电位（LTP）和低Mg 2+诱导的突触易化（LMISF）。在两个品系中，从癫痫发作小鼠获得的切片中的LTP和LMISF的幅度显著大于从未发作小鼠获得的切片。N-甲基-D-天冬氨酸（NMDA）受体拮抗剂AP-5可显著降低癫痫发作诱导的LTP和LMISF增强。非竞争性NMDA受体拮抗剂MK 801可降低B6小鼠的诱发效率，并可消除D2小鼠和诱发B6小鼠的AGS，提示听源性惊厥可通过激活NMDA受体增强突触易化。
The influence of audiogenic seizures (AGS) on synaptic facilitation was studied in DBA/2J (D2) and C57BL/6J (B6) mice. AGS susceptibility is inherited in D2 mice, but can be acquired in AGS‐resistant B6 mice through acoustic priming. The experiments were per formed on hippocampal slices obtained from D2 and B6 mice both with and without seizures. Long‐term potenti ation (LTP) and low‐Mg2 +‐induced synaptic facilitation (LMISF) were evaluated after stimulation of Schaffer col laterals. The magnitude of LTP and LMISF was signifi cantly greater in slices obtained from mice with seizures than from mice without seizures in both strains. Seizure induced enhancement of LTP and LMISF was markedly reduced by the JV‐methyl‐D‐aspartate (NMDA) receptor antagonist AP‐5. The noncompetitive NMDA receptor antagonist MK 801 reduced the efficiency of priming in B6 mice and abolished AGS in D2 mice and primed B6 mice, the data suggest that audiogenic seizures can en hance synaptic facilitation through activation of the NMDA receptor.