HUMAN VARIATION IN SKELETAL-MUSCLE FIBER-TYPE PROPORTION AND ENZYME-ACTIVITIES
HUMAN VARIATION IN SKELETAL-MUSCLE FIBER-TYPE PROPORTION AND ENZYME-ACTIVITIES
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DOI：
10.1152/ajpendo.1989.257.4.e567
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发表时间：
1989-10-01
影响因子：
--
通讯作者：
BOUCHARD, C
中科院分区：
文献类型：
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作者：
SIMONEAU, JA;BOUCHARD, C
本研究的目的是描述人类骨骼肌一些共同特征的变异程度。总共从 270 名久坐的健康人和 148 名身体活跃的男女的股外侧肌中获得了 418 份活检样本。观察到的 I 型肌纤维比例最低和最高分别为 15% 和 85%。变异系数（CV）达到.apprx。 I型和IIA型纤维的比例为30%，IIB型纤维的比例高出两倍。最小和最大平均肌纤维横截面积（CSA）为.apprx。分别为1,100 .mu.m2 和9,500 .mu.m2。各种纤维类型的平均 CSA 表现出 CV 为 .apprx。 23%。肌酸激酶活性的 CV 达到 30%，糖酵解酶标记物的 CV 范围在 28% 到 41% 之间，有氧氧化酶标记物的 CV 范围在 34% 到 44% 之间。男性肌肉中 I 型纤维的平均比例低于女性肌肉，而女性肌肉中所有纤维类型的平均 CSA 均小于男性肌肉。男性骨骼肌中糖酵解酶标记物的水平高于女性骨骼肌。然而，男性和女性的有氧氧化酶标记物的活性相似。这些结果揭示了人类骨骼肌最常见特征存在较大的个体差异和性别差异。
The purpose of the present study was to describe the extent of the variation in some of the common characteristics of human skeletal muscle. A total of 418 biopsies was obtained from the vastus lateralis muscle of 270 healthy sedentary and 148 physically active individuals of both sexes. The lowest and highest proportion of type I muscle fiber observed were 15 and 85%, respectively. Coefficients of variations (CV) reached .apprx. 30% for the proportion of types I and IIA fibers and were two times higher for the proportion of type IIB fiber. The smallest and largest mean muscle fiber cross-sectional areas (CSA) were .apprx. 1,100 .mu.m2 and 9,500 .mu.m2, respectively. Mean CSA of the various fiber types exhibited CV of .apprx. 23%. CV reached 30% for the activity of creatine kinase, ranged between 28 and 41% for the glycolytic enzyme markers, and between 34 and 44% for the aerobic-oxidative enzyme markers. The mean proportion of type I fiber was lower in male than in female muscles, whereas the mean CSA of all fiber types was smaller in female than in male muscles. Levels of glycolytic enzyme markers were higher in male than in female skeletal muscles. However, activities of aerobic-oxidative enzyme markers were similar in males and females. These results reveal the existence of large interindividual variability and gender differences in the most common characteristics of the human skeletal muscle.