Bone Marrow Adipose Tissue and Skeletal Health.
Bone Marrow Adipose Tissue and Skeletal Health.
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DOI：
10.1007/s11914-018-0451-y
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发表时间：
2018-08
影响因子：
4.3
通讯作者：
Sinal CJ
中科院分区：
文献类型：
--
作者：
Muruganandan S;Govindarajan R;Sinal CJ
总结和讨论骨髓脂肪细胞形成的最新进展和新的信号机制及其在骨重建中的生理/病理生理意义。骨重建是一个协调的过程，需要去除旧骨和形成新骨。几种骨丢失疾病如骨质疏松症通常与骨髓脂肪组织增加有关。实验和临床证据支持以脂肪生成为代价的间充质干细胞成骨细胞生成的减少，以及脂肪细胞来源的信号传导的有害作用，有助于骨质疏松症的病因学以及与衰老、糖尿病、绝经后和慢性药物治疗相关的骨丢失。然而，这一观点受到了研究结果的挑战，这些研究结果表明，在某些情况下，骨髓脂肪组织可能对骨骼健康有有益的影响。需要进一步的研究来更好地确定骨髓脂肪细胞在骨生理学/病理生理学中的作用，并确定操纵间充质干细胞分化的治疗潜力。
To summarize and discuss recent progress and novel signaling mechanisms relevant to bone marrow adipocyte formation and its physiological/pathophysiological implications for bone remodeling. Skeletal remodeling is a coordinated process entailing removal of old bone and formation of new bone. Several bone loss disorders such as osteoporosis are commonly associated with increased bone marrow adipose tissue. Experimental and clinical evidence supports that a reduction in osteoblastogenesis from mesenchymal stem cells at the expense of adipogenesis, as well as the deleterious effects of adipocyte-derived signaling, contributes to the etiology of osteoporosis as well as bone loss associated with aging, diabetes mellitus, post-menopause, and chronic drug therapy. However, this view is challenged by findings indicating that, in some contexts, bone marrow adipose tissue may have a beneficial impact on skeletal health. Further research is needed to better define the role of marrow adipocytes in bone physiology/pathophysiology and to determine the therapeutic potential of manipulating mesenchymal stem cell differentiation.
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