The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
The cerebrospinal fluid production rate is reduced in dementia of the Alzheimer's type
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DOI：
10.1212/wnl.57.10.1763
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发表时间：
2001-11-27
期刊：
影响因子：
9.9
通讯作者：
Saul, TA
中科院分区：
文献类型：
--
作者：
Silverberg, GD;Heit, G;Saul, TA
目的：评估不同疾病状态患者脑脊液的产生率。方法：作者测量了三组患者的脑脊液生成率：5 名 60 岁以下的 PD 患者（年龄 51 +/- 4 岁，平均 +/- SD）、9 名 60 岁以上的 PD 患者（年龄 69 +/- 6 岁，平均 +/- SD）和 7 名阿尔茨海默病型痴呆 (AD) 患者（年龄 72 +/- 9 岁，平均 +/- SD）。该方法基于 Masserman 技术，采用心室而不是腰椎进入脑脊液空间。此外，手术过程中取出的脑脊液体积仅为 3 mL，而不是 10 mL。结果：这些测量结果表明，60 岁以下 PD 患者的脑脊液产生平均速率为 0.47 +/- 0.13 mL/分钟，60 岁或以上 PD 患者的平均速率为 0.40 +/- 0.12 mL/分钟，AD 患者的平均速率为 0.20 +/- 0.06 mL/分钟。结论：这些结果表明PD患者的CSF产生率正常，而AD患者的CSF产生率明显降低。
Objective: To evaluate the production rate of CSF in patients with differing disease states. Methods: The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven with dementia of the Alzheimer's type (AD) (aged 72 +/- 9 years, mean +/- SD). This method, based on the Masserman technique, employs ventricular rather than a lumbar access to the CSF space. Furthermore, the volume of CSF removed during the procedure is only 3 mL rather than 10 mL. Results: These measurements indicate that the mean rate of CSF production in patients with PD under age 60 was 0.47 +/- 0.13 mL/minute, in patients with PD aged 60 or older the mean rate was 0.40 +/- 0.12 mL/minute, and in patients with AD the mean rate was 0.20 +/- 0.06 mL/minute. Conclusion: These results indicate that the rate of CSF production in patients with PD is normal, and that the rate of CSF production in patients with AD is markedly reduced.