Pd-catalyzed P-C cross-coupling reactions for versatile triarylphosphine synthesis.
Pd-catalyzed P-C cross-coupling reactions for versatile triarylphosphine synthesis.
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DOI：
10.1021/ol303448j
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发表时间：
2013-01
期刊：
影响因子：
5.2
通讯作者：
M. Hayashi;T. Matsuura;Ippei Tanaka;Hidetoshi Ohta;Y. Watanabe*
中科院分区：
文献类型：
--
作者：
M. Hayashi;T. Matsuura;Ippei Tanaka;Hidetoshi Ohta;Y. Watanabe*
通过钯催化的羟甲基膦衍生物的脱甲酰化P-C交叉偶联反应，已经实现了实用和通用的叔膦衍生物的合成。正交保护的前体的顺序偶联提供了一条简单而实用的路线，以获得各种具有任意组合的芳基取代基的叔膦衍生物。
Practical and versatile syntheses of tertiary phosphine derivatives have been achieved by palladium-catalyzed deformylative P-C cross-coupling reactions of hydroxymethylphosphine derivatives. Sequential couplings of orthogonally protected precursors provide a simple and practical route toward a variety of tertiary phosphine derivatives having aryl substituents in any combination.