Pharmacologic advantages of negative-balance isolated pelvic perfusion: achievement of intensive
Pharmacologic advantages of negative-balance isolated pelvic perfusion: achievement of intensive
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负平衡盆腔隔离灌注的药理学优势：实现强化
DOI：
10.1148/radiol.11102453
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发表时间：
2012
期刊：
影响因子：
19.7
通讯作者：
Murata S
中科院分区：
文献类型：
--
作者：
Motosugi U;Yamaguchi H;Furukawa T;Ichikawa T;Hatori T;Fujita I;Yamamoto M;Motoi F;Kanno A;Watanabe T;Koike N;Koyama I;Kobayashi J;Shimizu M.;Murata S
PurposeTo研究组织铂浓度和组织和血浆铂浓度之间的相关性后，负平衡孤立的盆腔灌注（NIPP）在猪model.Materials和MethodsAll动物实验进行根据大学动物护理和实验指南。顺铂（5 mg/kg体重）给药到球囊导管隔离的猪盆腔循环（n= 7），也全身给药到对照组（n= 7）。测量盆腔血液、全身血液、尿液、盆腔组织（子宫、膀胱、淋巴结和肌肉）和肾脏中的铂浓度。最大铂浓度比较两组的最大血药浓度（C-max）和血药浓度-时间曲线下面积（AUC）。（58.4 mg/L）和AUC（1163.6 mg/min/L）分别是全身C-max的44.9倍和56.2倍（1.3 mg/L）和AUC（20.7 mg/min/L），而对照组的相应值几乎相同。盆腔器官中的组织铂浓度是对照值的2.8-5.6倍。与对照组（8.1 mg/L）相比，NIPP组（1.0 mg/L）肾组织中的铂浓度显著降低。盆腔组织中的高铂浓度与高盆腔C-max和AUC相关性良好（P< .01）。结论NIPP的药理学优势是明显的，可实现高铂C-max、AUC和高盆腔组织浓度，而不会使全身器官暴露于铂。© RSNA，2011
PurposeTo study tissue platinum concentrations and the correlation between tissue and plasma platinum concentrations after negative-balance isolated pelvic perfusion (NIPP) in a porcine model.Materials and MethodsAll animal experiments were conducted according to the University Guidelines for Animal Care and Experimentation. Cisplatin (5 mg per kilogram of body weight) was administered into balloon catheter–isolated porcine pelvic circulations (n= 7) and also systemically to a control group (n= 7). Platinum concentrations in pelvic blood, systemic blood, urine, pelvic tissues (uterus, bladder, lymph nodes, and muscles), and kidneys were measured. Maximum platinum concentration (maximum serum drug concentration [C-max]) and area under the blood concentration–time curve (AUC) were compared between the two groups.ResultsWith NIPP, pelvic C-max (58.4 mg/L) and AUC (1163.6 mg⋅min/L) were 44.9- and 56.2-fold higher than systemic C-max (1.3 mg/L) and AUC (20.7 mg⋅min/L), respectively, whereas the corresponding values in the control group were almost identical. Tissue platinum concentrations in pelvic organs were 2.8–5.6-fold higher than the control values. Platinum concentrations in kidney tissue were markedly lower with NIPP (1.0 mg/L) compared with the controls (8.1 mg/L). High platinum concentrations in pelvic tissues correlated well (P< .01) with high pelvic C-max and AUC.ConclusionThe pharmacologic advantages of NIPP were evident, with achievement of high platinum C-max, AUC, and high pelvic tissue concentrations without exposing systemic organs to platinum.© RSNA, 2011