Immune and non-immune functions of adipose tissue leukocytes.
Immune and non-immune functions of adipose tissue leukocytes.
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脂肪组织白细胞的免疫和非免疫功能。
DOI：
10.1038/s41577-021-00635-7
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Lynch,L
中科院分区：
文献类型：
--
作者：
Trim,WV;Lynch,L
脂肪组织是一个复杂的动态器官，具有全身免疫代谢的影响。了解免疫细胞在脂肪组织中的作用的大部分工作都是在肥胖的背景下进行的。这些研究还揭示了脂肪组织白细胞发挥的一系列典型（免疫）和非典型功能。在这里，我们提供了一个概述脂肪组织免疫系统，包括其作为免疫水库在全身反应感染和作为一个网站的寄生虫和病毒感染的作用。我们还描述了脂肪组织内发现的专门免疫结构的功能作用。然而，我们的主要重点是最近发现的脂肪组织免疫细胞的“非免疫”功能，其中包括脂肪细胞稳态的调节，以及对营养状况和体温变化的反应。在此过程中，我们概述了脂肪组织免疫系统在健康和疾病中的治疗潜力。
Adipose tissue is a complex dynamic organ with whole-body immunometabolic influence. Much of the work into understanding the role of immune cells in adipose tissue has been in the context of obesity. These investigations have also uncovered a range of typical (immune) and non-typical functions exerted by adipose tissue leukocytes. Here we provide an overview of the adipose tissue immune system, including its role as an immune reservoir in the whole-body response to infection and as a site of parasitic and viral infections. We also describe the functional roles of specialized immunological structures found within adipose tissue. However, our main focus is on the recently discovered ‘non-immune’ functions of adipose tissue immune cells, which include the regulation of adipocyte homeostasis, as well as responses to changing nutrient status and body temperature. In doing so, we outline the therapeutic potential of the adipose tissue immune system in health and disease.