Unexpected high plasma xanthine oxidoreductase activity in female subjects with low levels of uric acid
Unexpected high plasma xanthine oxidoreductase activity in female subjects with low levels of uric acid
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DOI：
10.1507/endocrj.ej18-0127
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发表时间：
2018-01-01
影响因子：
2
通讯作者：
Miura, Tetsuji
中科院分区：
文献类型：
--
作者：
Furuhashi, Masato;Mori, Kazuma;Miura, Tetsuji
低尿酸血症是运动性急性肾损伤（EIAKI）的高危因素，可能是由于缺乏尿酸的抗氧化作用。黄嘌呤氧化还原酶（XOR）是一种催化次黄嘌呤和黄嘌呤形成尿酸的酶，导致超氧化物和活性氧的增加。已经提出XOR的激活促进氧化应激相关的组织损伤。我们使用液相色谱和三重四极杆质谱相结合的灵敏准确的测定方法，测量了尿酸水平相对较低的受试者的血浆XOR活性（
Hypouricemia is a high-risk factor of exercise-induced acute kidney injury (EIAKI) probably through a lack of an antioxidant effect of uric acid. Xanthine oxidoreductase (XOR) is an enzyme that catalyzes the formation of uric acid from hypoxanthine and xanthine, leading to an increase in superoxide and reactive oxygen species. Activation of XOR has been proposed to promote oxidative stress-related tissue injury. We measured plasma XOR activity by a sensitive and accurate assay using a combination of liquid chromatography and triple quadrupole mass spectrometry in subjects with relatively low levels of uric acid (