Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
Central ghrelin increases anxiety in the Open Field test and impairs retention memory in a passive avoidance task in neonatal chicks
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DOI：
10.1016/j.nlm.2008.12.008
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发表时间：
2009-05-01
影响因子：
2.7
通讯作者：
Salvatierra, Nancy A.
中科院分区：
文献类型：
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作者：
Carvajal, Pedro;Carlini, Valeria P.;Salvatierra, Nancy A.
生长素释放肽 (Grh) 是生长激素促分泌素受体的内源性配体。虽然 Ghr 会刺激大鼠的摄食，但它会抑制新生雏鸡的摄食。然而，人们对 Ghr 的其他主要行为影响知之甚少。因此，我们分别在旷场测试和单次被动回避任务中研究了脑室内注射的 Ghr 对新生雏鸡焦虑和记忆保留的影响。在旷场测试中，以剂量依赖性方式施用 Ghr 增加了行走潜伏期，但降低了行走活动，表明具有致焦虑作用。此外，接受被动回避任务训练并在训练后立即注射 30 pmol Ghr 的小鸡表现出记忆保留受损。然而，在预训练、训练、保留和辨别过程中，啄食次数没有显着影响。此外，不同剂量的Ghr在注射后不同时间对食物摄入产生抑制作用。我们的结果表明 Ghr 会诱导雏鸡产生焦虑。此外，我们首次证明 Ghr 可以降低非哺乳动物物种的记忆保留，这表明 Ghr 可能在鸟类的记忆保留过程中发挥重要作用。 (C) 2009 Elsevier Inc. 保留所有权利。
Ghrelin (Grh) is an endogenous ligand for the growth hormone secretagogue receptor. Although Ghr stimulates feeding in rats, it inhibits feeding in neonatal chicks. However, little is known about other central behavioral effects of Ghr. Therefore, we investigated the Ghr effects, injected intracerebroventricularly, on anxiety and memory retention of neonatal chicks in an Open Field test and in a one-trial passive avoidance task, respectively. In the Open Field test, the administration of Ghr in a dose-dependent manner increased the latency to ambulate but decreased ambulation activity, indicating an anxiogenic effect. Furthermore, chicks trained on a passive avoidance task and injected with a dose of 30 pmol of Ghr immediately after training showed an impairment of memory retention. However, there were no significant effects on the number of pecks during the pretraining, training, retention and discrimination. In addition, different doses of Ghr produced an inhibition in food intake at different times after injection. Our results indicate that Ghr induces anxiogenesis in chicks. Moreover, we have shown for the first time that Ghr can decrease memory retention in a non-mammalian species, suggesting that Ghr may play an important role in the processes of memory retention in birds. (C) 2009 Elsevier Inc. All rights reserved.