CHMIS-C: A comprehensive herbal medicine information system for cancer
CHMIS-C: A comprehensive herbal medicine information system for cancer
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DOI：
10.1021/jm049838d
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发表时间：
2005-03-10
影响因子：
7.3
通讯作者：
Wang, SM
中科院分区：
文献类型：
--
作者：
Fang, XL;Shao, L;Wang, SM
开发了一个综合性的中草药抗癌信息系统(CHMIS-C)。目前版本的数据库整合了临床上用于治疗不同类型癌症的200多种抗癌草药配方、900种单独成分和8500种从草药中分离出来的有机小分子的信息。此外，还建立了文献参考文献和分子靶标的辅助数据库。已经开发了一些基于网络的搜索工具，并将其整合到信息系统中，以实现高效的数据挖掘。数据库中的化合物已经链接到国家癌症研究所数据库中的相应条目，以及美国食品和药物管理局批准的药物数据库。本白皮书描述了各个附属数据库、整个数据库的集成以及数据挖掘工具。我们证明，这个综合信息系统可以作为抗癌药物开发的有效信息学工具。
A comprehensive herbal medicine information system for cancer (CHMIS-C) has been developed. The current version of the database integrates information on more than 200 anticancer herbal recipes that have been used for the treatment of different types of cancer in clinic, 900 individual ingredients, and 8500 small organic molecules isolated from herbal medicines. Furthermore, subsidiary databases of literature references and molecular targets have been constructed. A number of web-based searching tools have been developed and integrated into the information system for efficient data mining. The compounds in the database have been linked to the corresponding entries in the National Cancer Institute's database, and to a database of drugs approved by the U.S. Food and Drug Administration. This paper provides a description of the individual subsidiary databases, integration of the entire database, and data mining tools. We demonstrate that this comprehensive information system may be used as an effective informatics tool for anticancer drug discovery.